{"id":"W4284711655","doi":"10.1016/j.celrep.2022.111031","title":"EPH receptor tyrosine kinases phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; PROTEO; Centre hospitalier universitaire de Québec","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Erythropoietin-producing hepatocellular (Eph) receptor; Scaffold protein; Cell biology; Ephrin; Phosphorylation; Receptor tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; Signal transduction; Kinase; Biology; Cell migration; Cell signaling; Cell adhesion; Receptor; Chemistry; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006883125,0.0002523029,0.0002119886,0.0000383082,0.0005694643,0.0000710288,0.0002537497,0.0001000818,0.0007774694],"category_scores_gemma":[0.00004158875,0.0001859419,0.0001742398,0.0002222958,0.00003676036,0.000004578373,0.0003861562,0.0001971463,0.000008253306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003878622,"about_ca_system_score_gemma":0.00008007146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005637862,"about_ca_topic_score_gemma":0.000004077621,"domain_scores_codex":[0.9980344,0.0001139306,0.0004490637,0.0006467297,0.0003098621,0.0004460354],"domain_scores_gemma":[0.9987933,0.00001191542,0.0002740847,0.0006846244,0.00007952224,0.0001565728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007091481,0.00006937773,0.0001754645,0.000007212552,0.0000272116,0.00007538719,0.00004880396,0.03883683,0.9534459,0.00000806263,0.003591581,0.003643217],"study_design_scores_gemma":[0.0001357605,0.00030088,0.00002152309,0.00001695586,0.00001838078,0.00006062009,0.00009816625,0.0003862141,0.9008549,0.00008186842,0.09774721,0.0002774702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934452,0.001486499,0.002713456,0.0001516059,0.0007545015,0.0007770088,0.000008318733,0.00003873052,0.0006247212],"genre_scores_gemma":[0.9920831,0.00003802543,0.0008902614,0.0003987844,0.0003750526,0.0003154707,0.0001617751,0.00005830698,0.00567921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09415563,"threshold_uncertainty_score":0.8512744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006571761459467985,"score_gpt":0.2009160445648635,"score_spread":0.1943442831053955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}