{"id":"W4284711655","doi":"10.1016/j.celrep.2022.111031","title":"EPH receptor tyrosine kinases phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; PROTEO; Centre hospitalier universitaire de Québec","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"Erythropoietin-producing hepatocellular (Eph) receptor; Scaffold protein; Cell biology; Ephrin; Phosphorylation; Receptor tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; Signal transduction; Kinase; Biology; Cell migration; Cell signaling; Cell adhesion; Receptor; Chemistry; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009346883,0.0002595047,0.0001118928,0.0001264183,0.000158681,0.0002882663,0.0001213976,0.0001440281,0.001252824],"category_scores_gemma":[0.0001006026,0.000106265,0.0002070835,0.0001104596,0.0001684051,0.0002997458,0.0002714676,0.0002866933,0.000548226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003799432,"about_ca_system_score_gemma":0.0001307769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003009829,"about_ca_topic_score_gemma":0.0005256021,"domain_scores_codex":[0.9999156,0.00001236816,0.000004508036,0.00001732251,0.00002635108,0.00002386685],"domain_scores_gemma":[0.9999479,0.000009947255,0.00001892966,0.000005296295,0.000005457293,0.00001240052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004720438,0.000005980817,0.0002566023,0.000009462327,0.000002394391,0.00005282759,0.000007472971,0.00005869678,0.9986614,0.0002321461,0.00002796473,0.0006377835],"study_design_scores_gemma":[0.00001085997,0.00004810943,0.009360198,0.000001870598,0.00000740575,0.0002428953,0.00002552165,0.001622687,0.9870353,0.0001781946,0.001463954,0.000003045657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912882,0.0006327648,0.005831468,0.0001086153,0.00001422521,0.00001368667,0.000206249,0.00006521991,0.001839519],"genre_scores_gemma":[0.9958189,0.0004416258,0.002286285,0.00003023253,0.000006683771,0.00001132189,0.0002039032,0.00001283886,0.001188355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001252824,"threshold_uncertainty_score":0.00419116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006571761459467985,"score_gpt":0.2009160445648635,"score_spread":0.1943442831053955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}