{"id":"W4284886202","doi":"10.1038/s41564-022-01143-7","title":"SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway","year":2022,"lang":"en","type":"article","venue":"Nature Microbiology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":724,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; Engineering and Physical Sciences Research Council; Sheffield Teaching Hospitals NHS Foundation Trust; NIHR Oxford Biomedical Research Centre; St George's University Hospitals NHS Foundation Trust; Oxford University Hospitals NHS Foundation Trust; Barts Health NHS Trust; Great Ormond Street Hospital for Children; Liverpool University Hospitals NHS Foundation Trust; Newcastle upon Tyne Hospitals NHS Foundation Trust; Cambridge University Hospitals; Cardiff University; University of Glasgow; University of Nottingham; National Institute for Health Research Health Protection Research Unit; University of Oxford; Biotechnology and Biological Sciences Research Council; Wellcome Trust; Nottingham University Hospitals NHS Trust; University College London; Imperial College Healthcare NHS Trust; Directorate for Biological Sciences; Imperial College London; Bournemouth University; University of Cambridge; Academy of Medical Sciences; National Institute for Health and Care Research; Medical Research Council; Department of Health and Social Care; University Hospitals Birmingham NHS Foundation Trust; Betsi Cadwaladr University Health Board; Great Ormond Street Institute of Child Health; Newcastle University; Alan Turing Institute; King's College London; University Hospitals of Leicester NHS Trust; King's College Hospital NHS Foundation Trust; UK Research and Innovation; University of Portsmouth; Northumbria University","keywords":"Endosome; Biology; Antigenicity; Virology; In vitro; Neutralization; Lipid bilayer fusion; Viral entry; Immune system; Receptor; Cell biology; Genetics; Antibody; Virus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009088557,0.0003595719,0.0002215006,0.0001111116,0.0001724944,0.0002198089,0.00009857106,0.0002851765,0.001074085],"category_scores_gemma":[0.000171253,0.00008607646,0.0001738252,0.0001143106,0.000178895,0.0001152702,0.000191366,0.0004723134,0.0002883738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002033502,"about_ca_system_score_gemma":0.0001347644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008365685,"about_ca_topic_score_gemma":0.001104501,"domain_scores_codex":[0.9998882,0.00001718806,0.000007907439,0.00002642122,0.0000293457,0.00003097127],"domain_scores_gemma":[0.9999228,0.00001237984,0.00002561209,0.00001098836,0.000008022456,0.00002026555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002351637,0.0001029403,0.004758718,0.00001368475,0.000009029956,0.0005485895,0.0000404849,0.00005323228,0.9919952,0.0001254035,0.0001000551,0.002017502],"study_design_scores_gemma":[0.0002309327,0.007061295,0.2914372,0.00003269004,0.00006460935,0.03816508,0.0006358509,0.003852302,0.6455314,0.0005553183,0.01238257,0.00005076487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990706,0.00005634233,0.0001944766,0.00003583622,0.000007132231,0.000007035572,0.00006881083,0.000007743676,0.0005520246],"genre_scores_gemma":[0.9985521,0.00004557469,0.0004227314,0.00006620071,0.000007595738,0.000006059121,0.0002599886,0.000008207298,0.0006314541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001074085,"threshold_uncertainty_score":0.003593147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01695115309945975,"score_gpt":0.2949129327365689,"score_spread":0.2779617796371091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}