{"id":"W4284887384","doi":"10.1128/iai.00153-22","title":"Tauroursodeoxycholic Acid Inhibits Clostridioides difficile Toxin-Induced Apoptosis","year":2022,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"National Institute of General Medical Sciences","keywords":"Tauroursodeoxycholic acid; Ursodeoxycholic acid; Biology; Deoxycholic acid; Bile acid; Microbiology; Apoptosis; Clostridium difficile toxin A; Taurine; Toxin; Clostridium difficile toxin B; Antibiotics; Clostridium difficile; Pharmacology; Amino acid; Biochemistry; Unfolded protein response","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001640165,0.0004846982,0.0003850343,0.0003843415,0.0002306826,0.000239752,0.0002428757,0.0003261798,0.00270104],"category_scores_gemma":[0.0001919211,0.0001117892,0.000255501,0.0002729186,0.0001954649,0.0001589757,0.0001764565,0.0006674812,0.0005771192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002528177,"about_ca_system_score_gemma":0.0004794279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006799835,"about_ca_topic_score_gemma":0.001834413,"domain_scores_codex":[0.9998802,0.00002761698,0.00001338214,0.00001081546,0.00002256119,0.00004547564],"domain_scores_gemma":[0.9998895,0.00001988657,0.00002415453,0.00001620961,0.00002107149,0.00002911765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007043581,0.001279912,0.0008494119,0.0004256736,0.00007717247,0.0002407904,0.00008000901,0.0005101983,0.9394,0.0002810409,0.001825175,0.04798714],"study_design_scores_gemma":[0.001078199,0.0147802,0.01218156,0.00006542408,0.00007286794,0.0005249364,0.0001128806,0.001252754,0.9581245,0.0001723931,0.01161834,0.00001591084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836298,0.009973117,0.0006252518,0.000317023,0.0002312137,0.00006856593,0.0003556905,0.0001773002,0.004622035],"genre_scores_gemma":[0.9893703,0.005184957,0.0006036423,0.0001058483,0.00005627947,0.00005543521,0.000553204,0.00001686725,0.004053411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00270104,"threshold_uncertainty_score":0.009035885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03646052315131956,"score_gpt":0.3012683002969532,"score_spread":0.2648077771456336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}