{"id":"W4284888181","doi":"10.1128/aac.00052-22","title":"Preclinical Evaluation of Recombinant Microbial Glycoside Hydrolases as Antibiofilm Agents in Acute Pulmonary Pseudomonas aeruginosa Infection","year":2022,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Institute of Infection and Immunity; Hospital for Sick Children; McGill University; McGill University Health Centre","funders":"U.S. Army Materiel Command; Canadian Glycomics Network; U.S. Army; Cystic Fibrosis Canada","keywords":"Pseudomonas aeruginosa; Antibiotics; Microbiology; Biofilm; Ciprofloxacin; Antibiotic resistance; Ofloxacin; Immune system; Bacteria; Biology; Pharmacology; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009498182,0.0007657745,0.0008192234,0.0005301085,0.0002313901,0.0005559243,0.0006606096,0.0006863297,0.001191512],"category_scores_gemma":[0.0004747928,0.0003040209,0.0005611537,0.0003208753,0.0004296733,0.0005176325,0.0002468824,0.001738873,0.0002442622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003111826,"about_ca_system_score_gemma":0.000678259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006595716,"about_ca_topic_score_gemma":0.001458076,"domain_scores_codex":[0.9996013,0.0001333168,0.00002664148,0.00004168181,0.00009018077,0.0001067968],"domain_scores_gemma":[0.9995514,0.00008832145,0.0001003982,0.00003721552,0.00007204236,0.0001505057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007711771,0.01321031,0.0005048472,0.0005033226,0.0001069901,0.0001579468,0.00012266,0.001469758,0.9571396,0.000215733,0.0004116902,0.0184453],"study_design_scores_gemma":[0.002673215,0.3226861,0.004485965,0.00007086978,0.0002702965,0.0002767484,0.0001546053,0.002098317,0.662036,0.000139787,0.005082189,0.0000259342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909065,0.004197833,0.002267857,0.0003045065,0.0001327672,0.0006657821,0.0004193371,0.00008880927,0.001016577],"genre_scores_gemma":[0.9886435,0.005149395,0.003259934,0.00009268129,0.00006190088,0.0004080247,0.0005478659,0.00001928229,0.001817444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001191512,"threshold_uncertainty_score":0.005023181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.024566368289436,"score_gpt":0.3030535899894801,"score_spread":0.2784872217000441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}