{"id":"W4284894237","doi":"10.1186/s12916-022-02420-2","title":"Risk and benefit for umbrella trials in oncology: a systematic review and meta-analysis","year":2022,"lang":"en","type":"review","venue":"BMC Medicine","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Uniwersytet Jagielloński w Krakowie; Narodowe Centrum Nauki; Fundacja na rzecz Nauki Polskiej","keywords":"Medicine; Internal medicine; Meta-analysis; Clinical trial; Oncology; Confidence interval; Adverse effect; Targeted therapy; Publication bias; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006714053,0.0003543299,0.01050682,0.0002029697,0.0000531064,0.00001041038,0.0001863441,0.0002159483,0.000144917],"category_scores_gemma":[0.00798509,0.0002220122,0.001321582,0.0002857339,0.00006605481,8.022024e-7,0.0001627712,0.0001501849,6.037631e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000482888,"about_ca_system_score_gemma":0.0001785625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000855881,"about_ca_topic_score_gemma":0.0005185557,"domain_scores_codex":[0.9967032,0.0007157516,0.001684049,0.0005998581,0.0001190734,0.0001780438],"domain_scores_gemma":[0.9949979,0.002992205,0.001297363,0.0005662697,0.00004104282,0.0001051735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00001702792,0.00003184386,0.000004049089,0.9317487,0.05533803,0.000003963083,0.00001955472,0.000002749992,6.262447e-7,0.0001054965,0.001844263,0.01088373],"study_design_scores_gemma":[0.000272994,0.0002106981,3.435123e-7,0.003344838,0.5218371,0.00001493965,0.00001173596,0.000002122867,1.111052e-7,0.00003804504,0.4741387,0.0001284608],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000001580859,0.9949926,0.0002547847,0.0001152405,0.00006142232,0.003855193,0.0006413352,0.000002687711,0.00007522207],"genre_scores_gemma":[0.000001994232,0.9952469,0.0003216798,0.0006473422,0.0001305396,0.002437874,0.0006883235,0.00003078047,0.000494521],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9284039,"threshold_uncertainty_score":0.9559475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2181839373661507,"score_gpt":0.435700235680657,"score_spread":0.2175162983145063,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}