{"id":"W4284896104","doi":"10.1212/wnl.0000000000200898","title":"Association of Pace of Aging Measured by Blood-Based DNA Methylation With Age-Related Cognitive Impairment and Dementia","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Servier; Eisai; H. Lundbeck A/S; Research Councils UK; Northern California Institute for Research and Education; Foundation for the National Institutes of Health; University of Otago; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; University of Southern California; North Carolina Biotechnology Center; IXICO; Genentech; Sage Foundation; Alzheimer's Association; Russell Sage Foundation; Alzheimer's Disease Neuroimaging Initiative; Medical Research Council; Meso Scale Diagnostics; U.S. Department of Defense; National Science Foundation","keywords":"Dementia; Cognitive impairment; DNA methylation; Medicine; Association (psychology); Cognitive aging; Cognition; Ageing; Neuroscience; Gerontology; Psychology; Psychiatry; Genetics; Internal medicine; Biology; Disease; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003782861,0.00007838427,0.0001268804,0.00004746614,0.00005603742,0.000002922234,0.00004278898,0.00007543811,0.00001744692],"category_scores_gemma":[0.00004740451,0.00008149078,0.00003017206,0.00009053681,0.00004618744,0.000001819023,0.00004490708,0.0000844103,9.056752e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005590726,"about_ca_system_score_gemma":0.00003383944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003227683,"about_ca_topic_score_gemma":0.0000290893,"domain_scores_codex":[0.9990177,0.0003153271,0.0001919227,0.0002002625,0.0001629404,0.0001118281],"domain_scores_gemma":[0.9994403,0.00005113819,0.0002997793,0.00008858427,0.00009641323,0.00002381204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002285822,0.000115576,0.07792977,0.00001309608,0.0001998779,0.000001690959,0.00006856802,0.0008374547,0.9201638,0.000007628376,0.00003118437,0.0004027881],"study_design_scores_gemma":[0.002090222,0.003799573,0.04569147,0.000003191365,0.0002620175,0.000001732384,0.00001845784,0.0002313771,0.9471333,0.00008013989,0.000589902,0.00009863498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977286,0.001056396,0.0005869219,0.0002802474,0.00004245304,0.0001806093,0.00004046933,0.000004561025,0.00007974193],"genre_scores_gemma":[0.9994881,0.00005125753,0.00008715203,0.00009981894,0.000007928988,0.00001927047,0.0002035121,0.00001171665,0.00003130272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0322383,"threshold_uncertainty_score":0.3323097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005990291701435186,"score_gpt":0.2196075873887314,"score_spread":0.2136172956872962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}