{"id":"W4284896104","doi":"10.1212/wnl.0000000000200898","title":"Association of Pace of Aging Measured by Blood-Based DNA Methylation With Age-Related Cognitive Impairment and Dementia","year":2022,"lang":"en","type":"article","venue":"Neurology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Servier; Eisai; H. Lundbeck A/S; Research Councils UK; Northern California Institute for Research and Education; Foundation for the National Institutes of Health; University of Otago; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; University of Southern California; North Carolina Biotechnology Center; IXICO; Genentech; Sage Foundation; Alzheimer's Association; Russell Sage Foundation; Alzheimer's Disease Neuroimaging Initiative; Medical Research Council; Meso Scale Diagnostics; U.S. Department of Defense; National Science Foundation","keywords":"Dementia; Cognitive impairment; DNA methylation; Medicine; Association (psychology); Cognitive aging; Cognition; Ageing; Neuroscience; Gerontology; Psychology; Psychiatry; Genetics; Internal medicine; Biology; Disease; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001473886,0.0002204585,0.0001929455,0.0004880625,0.0004346477,0.0004376566,0.0004268808,0.0003888521,0.002006141],"category_scores_gemma":[0.004771911,0.0001891411,0.0003961558,0.0004974249,0.0002487075,0.0002421331,0.0003326779,0.0004552536,0.0001969389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003913441,"about_ca_system_score_gemma":0.0003256624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01728608,"about_ca_topic_score_gemma":0.01833139,"domain_scores_codex":[0.9993754,0.0002024018,0.00005455337,0.000234616,0.00007457906,0.00005847322],"domain_scores_gemma":[0.9980524,0.0005378909,0.0005859677,0.0003871031,0.0002566369,0.0001800872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004890915,0.00003298908,0.9939967,0.00001360775,0.0002018124,0.00002841586,0.0001035014,0.0001869461,0.0006093608,0.00008722021,0.000592455,0.003657877],"study_design_scores_gemma":[0.00001870968,0.000106267,0.9983383,0.000004883471,0.00007089797,0.0000690747,0.00003703251,0.000400951,0.0003117616,0.0001070967,0.0005287621,0.000006195043],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954053,0.000152566,0.001043148,0.0001206719,0.00002942928,0.00004340656,0.002190877,0.00001895668,0.0009957369],"genre_scores_gemma":[0.9964289,0.00005818317,0.0012319,0.0001036724,0.0000225453,0.00006699896,0.00133224,0.0000109949,0.0007445007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01728608,"threshold_uncertainty_score":0.03437096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005990291701435186,"score_gpt":0.2196075873887314,"score_spread":0.2136172956872962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}