{"id":"W4284896194","doi":"10.1021/acs.bioconjchem.2c00284","title":"Toward Bifunctional Chelators for Thallium-201 for Use in Nuclear Medicine","year":2022,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; TRIUMF","funders":"EPSRC Centre for Doctoral Training in Medical Imaging; Engineering and Physical Sciences Research Council; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Rosetrees Trust; Cancer Research UK; Wellcome Trust; Wellcome","keywords":"Chemistry; Biodistribution; Bifunctional; Spect imaging; DU145; Radiochemistry; DOTA; In vivo; Radionuclide therapy; Nuclear magnetic resonance spectroscopy; Chelation; Nuclear medicine; In vitro; Stereochemistry; Prostate cancer; Inorganic chemistry; Cancer; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007514191,0.0004305425,0.0001593358,0.0003029653,0.0002390743,0.000472849,0.0004858852,0.0006488462,0.002145727],"category_scores_gemma":[0.0005412723,0.0001826017,0.0001552781,0.0002032118,0.0003295402,0.0005726306,0.0004386155,0.0006116813,0.001165478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005451114,"about_ca_system_score_gemma":0.0004412807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007182529,"about_ca_topic_score_gemma":0.001892681,"domain_scores_codex":[0.9998559,0.00004207067,0.000009508157,0.0000244058,0.00004190626,0.00002612452],"domain_scores_gemma":[0.9998579,0.0000271919,0.00003087034,0.00001050286,0.00004637534,0.00002716297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000110147,0.00004512831,0.000120432,0.0002852121,0.000008204514,0.00008702892,0.00008195485,0.00032767,0.9775749,0.003860807,0.0015148,0.0159838],"study_design_scores_gemma":[0.00004188374,0.0004172127,0.0004333485,0.00010761,0.00002180828,0.0005154892,0.00005272657,0.002485992,0.9462596,0.000807701,0.04883204,0.00002470024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5052764,0.04109158,0.4119345,0.005000528,0.0004893332,0.001077002,0.0007704393,0.001630694,0.03272957],"genre_scores_gemma":[0.7686228,0.01996075,0.1916027,0.002016497,0.0000799642,0.0004948567,0.001119743,0.0002051886,0.01589754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002145727,"threshold_uncertainty_score":0.007178187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.100424685269055,"score_gpt":0.3264649780313246,"score_spread":0.2260402927622696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}