{"id":"W4284896612","doi":"10.1016/j.str.2022.05.022","title":"It takes two to tango: Rycals and ATP snuggle up to bind ryanodine receptors","year":2022,"lang":"en","type":"letter","venue":"Structure","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Ryanodine receptor; Receptor; Chemistry; Cell biology; Biophysics; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001955796,0.0007627371,0.0009233706,0.0003735226,0.003570572,0.003439398,0.001421275,0.0446067,0.004973989],"category_scores_gemma":[0.01074435,0.0007802678,0.0009621553,0.0002593159,0.003862997,0.003450631,0.001741323,0.03790396,0.004005319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00513964,"about_ca_system_score_gemma":0.002343363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003619453,"about_ca_topic_score_gemma":0.005677742,"domain_scores_codex":[0.9986822,0.0002776305,0.00008792149,0.0001961617,0.0005030409,0.0002530153],"domain_scores_gemma":[0.9977607,0.001065574,0.0002102183,0.0001626261,0.0002406655,0.0005603624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002428305,0.00006082224,0.0004060596,0.00004370671,0.00004111955,0.003119321,0.0001419456,0.000109049,0.001134031,0.01195963,0.969517,0.0132246],"study_design_scores_gemma":[0.0004893387,0.0001864646,0.0009873494,0.0001053499,0.00005403002,0.003561538,0.0004253733,0.0007783918,0.001763011,0.06283952,0.9287174,0.00009236049],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001235101,0.002421905,0.0003100668,0.9623265,0.02990124,0.00001188716,0.00002210441,0.00004491592,0.003726206],"genre_scores_gemma":[0.01384881,0.001609073,0.0003625088,0.930711,0.03762821,0.00004246439,0.00002201581,0.00002521171,0.01575066],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.0446067,"threshold_uncertainty_score":0.03729081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01024371750136636,"score_gpt":0.2616852392524486,"score_spread":0.2514415217510823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}