{"id":"W4284898359","doi":"10.1039/d2cs00099g","title":"Degradable polyprodrugs: design and therapeutic efficiency","year":2022,"lang":"en","type":"review","venue":"Chemical Society Reviews","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick","funders":"Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; Vidyasirimedhi Institute of Science and Technology; Nanjing Forestry University","keywords":"Therapeutic effect; Chemistry; Biochemical engineering; Pharmacology; Medicine; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004633172,0.001049113,0.0006575769,0.001102148,0.000115563,0.0006838249,0.0005164632,0.0008978512,0.001264312],"category_scores_gemma":[0.0002715375,0.0004326577,0.0002833866,0.0008639992,0.0004058341,0.0006888056,0.0003699515,0.001364133,0.001145086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007768265,"about_ca_system_score_gemma":0.0004486794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006225692,"about_ca_topic_score_gemma":0.001106303,"domain_scores_codex":[0.9998544,0.00002028996,0.0000136257,0.00003051478,0.00005533559,0.00002587418],"domain_scores_gemma":[0.9999375,0.00001985067,0.00001615654,0.000003255559,0.00001671248,0.000006464678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009291487,0.0001376316,0.00008890909,0.01040682,0.00006080596,0.000418019,0.0000874802,0.001328659,0.1104221,0.0146466,0.01172832,0.8505818],"study_design_scores_gemma":[0.00005454963,0.0004492561,0.0006581148,0.001279822,0.00007987161,0.001844736,0.00003324258,0.0006872213,0.05301529,0.002366576,0.9394946,0.00003670253],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001669215,0.9941106,0.001290464,0.0002416047,0.0002121884,0.0000269733,0.00002688021,0.00002039808,0.00240156],"genre_scores_gemma":[0.008421045,0.9856606,0.001919486,0.0002024165,0.00008743434,0.00004997971,0.00004299679,0.000006490913,0.003609691],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001264312,"threshold_uncertainty_score":0.005636275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08783317623389543,"score_gpt":0.3128824487648736,"score_spread":0.2250492725309782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}