{"id":"W4284958472","doi":"10.3390/cancers14143340","title":"Selective CDK9 Inhibition by Natural Compound Toyocamycin in Cancer Cells","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Cancer Institute","keywords":"Biology; Cyclin-dependent kinase; Chromatin; Molecular biology; Histone; Cancer cell; Gene silencing; Cyclin-dependent kinase 9; Kinase; Biochemistry; DNA; Gene; Genetics; Cancer; Protein kinase A; Cyclin-dependent kinase 2; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000703816,0.00009132666,0.00008355683,0.00003547409,0.0001259405,0.00001152935,0.00009543273,0.00003699546,0.0001298938],"category_scores_gemma":[0.000003243117,0.000102512,0.00003785835,0.0001877959,0.00004213667,0.000003980389,0.00005198692,0.0001517079,0.000002053251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009705751,"about_ca_system_score_gemma":0.0003636005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00118019,"about_ca_topic_score_gemma":0.0005874655,"domain_scores_codex":[0.9992695,0.00004971482,0.000116756,0.0002763634,0.0001064204,0.0001812894],"domain_scores_gemma":[0.9997286,0.000003896272,0.00005559804,0.0001428828,0.00003511499,0.00003397276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007478654,0.00001570056,0.0003904215,0.000005157962,0.00001630145,0.000001239984,0.00009544834,0.007176347,0.9006472,0.00002244905,0.09022158,0.001333415],"study_design_scores_gemma":[0.0009847329,0.0001719481,0.001139846,0.000009140758,0.000009510624,0.000004276556,0.0005332772,0.0006791254,0.7184374,0.00004682507,0.2776827,0.0003011646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931753,0.004668775,0.00007141814,0.0002161521,0.0004386611,0.00018593,0.0001716278,0.000008060609,0.001064034],"genre_scores_gemma":[0.9964551,0.0003831311,0.00002471212,0.0007800818,0.00009849392,0.000400597,0.0002054322,0.00001483421,0.001637639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1874612,"threshold_uncertainty_score":0.4180317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007425011231087812,"score_gpt":0.2501392497230114,"score_spread":0.2427142384919236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}