{"id":"W4284958472","doi":"10.3390/cancers14143340","title":"Selective CDK9 Inhibition by Natural Compound Toyocamycin in Cancer Cells","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Cancer Institute","keywords":"Biology; Cyclin-dependent kinase; Chromatin; Molecular biology; Histone; Cancer cell; Gene silencing; Cyclin-dependent kinase 9; Kinase; Biochemistry; DNA; Gene; Genetics; Cancer; Protein kinase A; Cyclin-dependent kinase 2; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005443618,0.0002526346,0.0002325365,0.0001085074,0.0000738461,0.0001243771,0.0001111465,0.0001335403,0.0005579048],"category_scores_gemma":[0.00007164603,0.00006573845,0.0001134582,0.0001311509,0.0001211126,0.00008108168,0.0001198652,0.0002086981,0.0002121277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001978942,"about_ca_system_score_gemma":0.0001336653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005946822,"about_ca_topic_score_gemma":0.0009113043,"domain_scores_codex":[0.9999468,0.0000117683,0.000005163634,0.0000161168,0.000009397137,0.00001073553],"domain_scores_gemma":[0.9999658,0.000009777869,0.000009100723,0.000004801391,0.000003573192,0.00000703766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006570369,0.000009745951,0.00005436731,0.00003611001,0.00000201485,0.00002243381,0.000003969918,0.0001271259,0.998571,0.00005393692,0.00001997031,0.001033531],"study_design_scores_gemma":[0.000009650523,0.0001178954,0.000443056,0.000002067888,0.000003552989,0.0000652754,0.000003583138,0.0003650093,0.9978059,0.00001296216,0.001169509,0.0000015276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861767,0.004858194,0.005413637,0.00009252492,0.0000271114,0.00005553727,0.0006418988,0.0001397728,0.002594595],"genre_scores_gemma":[0.9943535,0.001634923,0.002546949,0.00002179338,0.000004907526,0.00003162971,0.000340624,0.00001922945,0.001046387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005946822,"threshold_uncertainty_score":0.001866341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007425011231087812,"score_gpt":0.2501392497230114,"score_spread":0.2427142384919236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}