{"id":"W4284960909","doi":"10.1038/s41467-022-31695-5","title":"GLI3 regulates muscle stem cell entry into GAlert and self-renewal","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; Ottawa Hospital; University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche; AFM-Téléthon; Stem Cell Network; Ontario Institute for Regenerative Medicine; U.S. Department of Health and Human Services; Government of Canada; Muscular Dystrophy Association; French Muscular Dystrophy Association","keywords":"GLI3; Cell biology; mTORC1; Stem cell; Transcription factor; Biology; Cell growth; Cell fate determination; Chemistry; Signal transduction; PI3K/AKT/mTOR pathway; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008360519,0.0001452671,0.0001493977,0.0002436862,0.0001838166,0.000267465,0.0001628671,0.000180478,0.0009871682],"category_scores_gemma":[0.00007210985,0.0001196495,0.0001902465,0.0001274202,0.0002742606,0.0001246947,0.0002292084,0.0003415134,0.0003722294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005264181,"about_ca_system_score_gemma":0.0002591726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001296107,"about_ca_topic_score_gemma":0.002368763,"domain_scores_codex":[0.9999192,0.000009674864,0.000006305998,0.00001326944,0.00002326628,0.00002828698],"domain_scores_gemma":[0.9999133,0.00001122477,0.00002745121,0.000007464642,0.00001093949,0.00002956854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007844165,0.000007069773,0.0003947528,0.00001212877,0.000002018278,0.00003721459,0.000009807539,0.00003210687,0.998682,0.0001730884,0.00004473679,0.0005265835],"study_design_scores_gemma":[0.00001085109,0.00005976251,0.01303756,0.000004207307,0.000007070805,0.0001554984,0.00003230618,0.001152434,0.9836622,0.0001315932,0.001743433,0.000003067593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946148,0.0006912186,0.001902306,0.00009443441,0.00001299923,0.00001079234,0.0004189549,0.0001252739,0.002129131],"genre_scores_gemma":[0.9961546,0.0001913894,0.001013812,0.0000413515,0.000003525768,0.00001030358,0.0003056671,0.00003106179,0.002248346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001296107,"threshold_uncertainty_score":0.003819406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005116874707746793,"score_gpt":0.2337346579741172,"score_spread":0.2286177832663704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}