{"id":"W4284961026","doi":"10.3233/jad-220164","title":"Polygenic Scores of Alzheimer’s Disease Risk Genes Add Only Modestly to <i>APOE</i> in Explaining Variation in Amyloid PET Burden","year":2022,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute on Aging; Canadian Institutes of Health Research","keywords":"Apolipoprotein E; Variation (astronomy); Amyloid (mycology); Polygenic risk score; Amyloid β; Disease; Gene; Medicine; Alzheimer's disease; Psychology; Neuroscience; Genetics; Biology; Internal medicine; Pathology; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004954937,0.001563939,0.0007288387,0.001751312,0.0007061235,0.001378699,0.0006465125,0.0006772639,0.003472574],"category_scores_gemma":[0.01046848,0.000420471,0.001973154,0.001841447,0.001007105,0.0005952198,0.001062169,0.0009829121,0.000476332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002556793,"about_ca_system_score_gemma":0.0004151139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003874092,"about_ca_topic_score_gemma":0.00418591,"domain_scores_codex":[0.9962064,0.001942917,0.000334116,0.0007606212,0.0005181239,0.0002377848],"domain_scores_gemma":[0.9897982,0.005866253,0.001847734,0.001735665,0.0003533246,0.0003988974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000360353,0.00005053064,0.9856035,0.00002850759,0.001752758,0.0003019796,0.00009468164,0.001100034,0.00188099,0.0003310384,0.0002068323,0.008288949],"study_design_scores_gemma":[0.00001624231,0.0001085901,0.9928939,0.00001469849,0.0005702421,0.0005791403,0.00005821644,0.003819641,0.0002950295,0.001277784,0.0003519681,0.00001447384],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875777,0.0005528691,0.009149846,0.0002807873,0.00002956447,0.00003892793,0.000635243,0.00009632423,0.001638705],"genre_scores_gemma":[0.9978455,0.00007974803,0.001385006,0.0000368076,0.00002684835,0.00001607858,0.0004389264,0.00001809516,0.0001529609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004954937,"threshold_uncertainty_score":0.02620453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01996583039797126,"score_gpt":0.2794270981466639,"score_spread":0.2594612677486926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}