{"id":"W4284965543","doi":"10.1093/nar/gkac557","title":"P-bodies directly regulate MARF1-mediated mRNA decay in human cells","year":2022,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"P-bodies; Messenger RNA; Biology; Ribonucleoprotein; RNA-binding protein; RNA; Cell biology; Enhancer; Messenger RNP; Molecular biology; Gene expression; Translation (biology); Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002440073,0.0002319547,0.0002736695,0.0001984149,0.00019999,0.0004278402,0.0001623929,0.0002623206,0.002198839],"category_scores_gemma":[0.000360478,0.0001434296,0.0002802577,0.0001177421,0.0001915618,0.0001416606,0.0002781664,0.0003707838,0.000816577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003315971,"about_ca_system_score_gemma":0.0001621214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004879873,"about_ca_topic_score_gemma":0.0004664275,"domain_scores_codex":[0.9997665,0.00006771922,0.00001472297,0.00005979233,0.00004978899,0.00004140055],"domain_scores_gemma":[0.9998066,0.00008415055,0.00003411627,0.00003133389,0.00002170629,0.00002215194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002986444,0.00003658605,0.0003884273,0.00002967579,0.000008812479,0.00008631336,0.0000300734,0.0001175558,0.9954098,0.000157046,0.0001407323,0.003296322],"study_design_scores_gemma":[0.00002930183,0.0002046662,0.004164808,0.000004803401,0.0000117798,0.0002192441,0.00002262265,0.001581068,0.9889162,0.00008738212,0.004753675,0.000004465765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798293,0.006251849,0.009752449,0.0001730396,0.0000496576,0.00005543251,0.0003931618,0.0003050723,0.00318993],"genre_scores_gemma":[0.9913083,0.0009019561,0.003884952,0.00007243551,0.00001232254,0.00005229569,0.0006561714,0.00002679705,0.003084765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002198839,"threshold_uncertainty_score":0.007355869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02809541950153105,"score_gpt":0.3298090475846497,"score_spread":0.3017136280831186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}