{"id":"W4284965560","doi":"10.1101/2022.07.06.498924","title":"CryoEM Structures of the Human HIV-1 Restriction Factor SERINC3 and Function as a Lipid Transporter","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Common Fund; Canadian Institutes of Health Research; University of Virginia; University of California, San Francisco; Weill Cornell Medical College; National Cancer Institute; National Institutes of Health; Simons Foundation","keywords":"Infectivity; Phosphatidylethanolamine; Phosphatidylserine; Phospholipid scramblase; Biology; Viral envelope; Cell biology; Lipid bilayer; Glycerophospholipid; Transporter; ATP-binding cassette transporter; Phosphatidylcholine; Biochemistry; Chemistry; Glycoprotein; Phospholipid; Virology; Membrane; Virus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006453575,0.000149468,0.00006865666,0.00007927649,0.0003434987,0.0001919885,0.0001762853,0.0002443758,0.001933299],"category_scores_gemma":[0.000106224,0.00009670833,0.0001687364,0.00008261225,0.0001537508,0.0002065782,0.0001147095,0.0004741193,0.0003119683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005052083,"about_ca_system_score_gemma":0.000193196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003004926,"about_ca_topic_score_gemma":0.002301054,"domain_scores_codex":[0.9999869,0.000001095094,6.118401e-7,0.000002324513,0.000004799561,0.000004375612],"domain_scores_gemma":[0.9999522,0.00001373048,0.0000103692,0.000003102835,0.000009578976,0.00001110667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000649688,0.00007232798,0.003747481,0.0001495993,0.00003468515,0.0008991819,0.0001837946,0.00246289,0.9850962,0.001330534,0.001708179,0.003665576],"study_design_scores_gemma":[0.0001459152,0.0006407219,0.1066897,0.0001231701,0.0001053146,0.003539844,0.0007744064,0.0517845,0.8047729,0.001545525,0.02980948,0.00006849285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915814,0.000933979,0.002261195,0.000296001,0.0000289101,0.00001423123,0.0005024833,0.00006497034,0.004316927],"genre_scores_gemma":[0.9900428,0.0009798693,0.003211407,0.0001474726,0.00001174846,0.00001933305,0.002106044,0.00004659268,0.003434522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003004926,"threshold_uncertainty_score":0.006467581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01393926657664526,"score_gpt":0.2289601381795131,"score_spread":0.2150208716028678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}