{"id":"W4284968395","doi":"10.1101/2022.07.07.499185","title":"Architecture and dynamics of a novel desmosome-endoplasmic reticulum organelle","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institutes of Health; Gordon and Betty Moore Foundation; Howard Hughes Medical Institute","keywords":"Endoplasmic reticulum; Desmosome; Cell biology; Keratin; Cytoplasm; Intermediate filament; Cell junction; Organelle; Chemistry; Cytoskeleton; Biology; Biophysics; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006964585,0.00009129085,0.0001168692,0.0002951253,0.000362461,0.0005062832,0.000150618,0.0002044488,0.0008109709],"category_scores_gemma":[0.00009958586,0.0001010544,0.00008059372,0.0002233073,0.0001434136,0.0004541059,0.0002746521,0.0001600875,0.0003014961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002818943,"about_ca_system_score_gemma":0.0001401647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003008678,"about_ca_topic_score_gemma":0.0004795429,"domain_scores_codex":[0.9999583,0.000003463389,0.000002194706,0.00001304011,0.00001522969,0.000007790783],"domain_scores_gemma":[0.9999163,0.000007353022,0.00002265606,0.000008725396,0.00002130789,0.00002358253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007128889,0.00001484956,0.002499043,0.00007124519,0.000008679574,0.0004686302,0.0000713979,0.0006764641,0.9858946,0.005696613,0.0003349922,0.004192263],"study_design_scores_gemma":[0.00004863528,0.0003880532,0.1433211,0.00006533872,0.00006622893,0.005387479,0.0006152413,0.0670742,0.7253067,0.01177258,0.04587755,0.0000770042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838963,0.001306238,0.01134709,0.0001654865,0.0000487803,0.00001129706,0.0002538788,0.0001650551,0.002805971],"genre_scores_gemma":[0.9920082,0.0003650895,0.004887552,0.00001815597,0.0000210957,0.000006410302,0.000257681,0.00002117843,0.002414692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008109709,"threshold_uncertainty_score":0.002713025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006649339684699977,"score_gpt":0.1908382627472776,"score_spread":0.1841889230625776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}