{"id":"W4284988218","doi":"10.1002/adbi.202101326","title":"Genome‐Wide Polygenic Score Predicts Large Number of High Risk Individuals in Monogenic Undiagnosed Young Onset Parkinson's Disease Patients from India","year":2022,"lang":"en","type":"article","venue":"Advanced Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Parkinson's Clinic of Eastern Toronto & Movement Disorders Centre","funders":"","keywords":"Disease; Genetics; LRRK2; Biology; Polygenic risk score; Parkinson's disease; Genome-wide association study; Gene; Bioinformatics; Medicine; Genotype; Single-nucleotide polymorphism; Internal medicine; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002330856,0.0002097683,0.0002218993,0.000834064,0.0003556707,0.0006179255,0.0003041806,0.0002804419,0.001251569],"category_scores_gemma":[0.001199626,0.0001946373,0.0003336975,0.0008029929,0.0003405624,0.0001311423,0.0003932317,0.0003380871,0.0002378506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001686409,"about_ca_system_score_gemma":0.0002070233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006764518,"about_ca_topic_score_gemma":0.00574802,"domain_scores_codex":[0.9997066,0.0000760823,0.00003616721,0.00008212357,0.00004571035,0.00005334758],"domain_scores_gemma":[0.9993488,0.0001726522,0.0001953754,0.00008795803,0.00005484487,0.0001404233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005786567,0.00001178769,0.9977148,0.00000424223,0.00003491346,0.0002703782,0.0001314536,0.000067424,0.0005742507,0.00002426908,0.00004726134,0.001061473],"study_design_scores_gemma":[0.000002331995,0.00002708218,0.9987111,0.000002098352,0.00001636771,0.0007855754,0.000126556,0.0001580266,0.00007684978,0.0000244031,0.00006645417,0.00000314615],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995298,0.00004078337,0.0000650082,0.00001343599,0.000001481776,0.00000269303,0.0000944281,0.000003499053,0.0002489373],"genre_scores_gemma":[0.9997103,0.00002714407,0.0000407786,0.000007632359,0.000001659858,0.000001710107,0.0001416264,0.000001360591,0.00006763925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006764518,"threshold_uncertainty_score":0.01345032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003702970835259159,"score_gpt":0.2614822648334307,"score_spread":0.2577792939981716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}