{"id":"W4284988981","doi":"10.1002/mds.29133","title":"The Interaction between <scp><i>HLA‐DRB1</i></scp> and Smoking in Parkinson's Disease Revisited","year":2022,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; Toronto Western Hospital; Occupational Cancer Research Centre; University of Toronto","funders":"National Institute of Environmental Health Sciences; National Institute on Aging; Faculty of Medicine and Health, University of Sydney; Instituto de Salud Carlos III; Medical Research Council; Pfizer Japan; Novartis Pharma; Parkinsonfonden; National Institutes of Health; Parkinson Vereniging; Ono Pharmaceutical; FP Pharmaceutical Corporation; Mitsubishi Tanabe Pharma Corporation; Skånes universitetssjukhus; Association France Parkinson; Medical Research Council Canada; Lunds Universitet; Norges Forskningsråd; Department of Forestry and Natural Resources, Purdue University; European Commission; Fondazione Pierfranco e Luisa Mariani; Ministero della Salute; Helse Sør-Øst RHF; Sanofi K.K.; Eesti Teadusagentuur; Daiichi Sankyo Europe; Karolinska Institutet; ZonMw; Biogen; Agence Nationale de la Recherche; Sanofi; Fondation de France; Idorsia Pharmaceuticals; Université Paris-Saclay; Department of Science and Technology, Ministry of Science and Technology, India; Fondation Roger de Spoelberch; South African Medical Research Council; Hersenstichting; Radboud Universiteit; National Research Foundation; University College London; Verily Life Sciences; Universiteit Stellenbosch; Parkinson's UK; Bundesministerium für Bildung und Forschung; Nasjonalforeningen for Folkehelsen; Boehringer Ingelheim Japan; Fondazione Cariplo; Kissei; Alexion Pharmaceuticals; EVER Neuro Pharma; Nihon Medi-Physics; Université du Luxembourg; Pfizer; EU Joint Programme – Neurodegenerative Disease Research; Teva Pharmaceutical Industries; Japan Society for the Promotion of Science; Astellas Pharma; Horizon 2020 Framework Programme; Vetenskapsrådet; Eisai; Boston Scientific Japan; Deutsche Forschungsgemeinschaft; Japan Agency for Medical Research and Development; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Ministerio de Ciencia e Innovación; UCB Pharma; Demensfonden; Meiji Seika Pharma; Hjärnfonden; U.S. Department of Defense; Mylan; Boston Scientific Corporation; Michael J. Fox Foundation for Parkinson's Research; Multiple Sclerosis Society of Western Australia; Consortium canadien en neurodégénérescence associée au vieillissement; Hellenic Foundation for Research and Innovation; General Secretariat for Research and Technology; Multiple System Atrophy Coalition; U.S. Department of Health and Human Services","keywords":"Odds ratio; Parkinson's disease; Single-nucleotide polymorphism; Confidence interval; Disease; Psychology; Mendelian randomization; Human leukocyte antigen; Genetics; Medicine; Internal medicine; Biology; Genotype; Gene; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003873869,0.0004810674,0.0006044109,0.0005097385,0.0004349558,0.0008412064,0.0006599828,0.0006847238,0.003205764],"category_scores_gemma":[0.005156795,0.0002111655,0.001067478,0.0007391224,0.0007413935,0.0002687038,0.0004147684,0.001100893,0.000246514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000239627,"about_ca_system_score_gemma":0.0003202595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003573898,"about_ca_topic_score_gemma":0.002326034,"domain_scores_codex":[0.9968691,0.002025547,0.0001119779,0.0006115835,0.0002388782,0.000142951],"domain_scores_gemma":[0.9914917,0.005423537,0.001366296,0.0008248609,0.0004782173,0.0004153184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002656257,0.00009870364,0.9758332,0.00009061702,0.001949781,0.0004190465,0.0001402373,0.0001955895,0.01018695,0.0002986929,0.000287831,0.007843028],"study_design_scores_gemma":[0.00007859412,0.0005214987,0.9936652,0.00003121771,0.001228335,0.0006685705,0.0001255504,0.0008546463,0.001767897,0.0004147039,0.0006324344,0.00001134159],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937872,0.003102377,0.001296892,0.0005968488,0.00003859482,0.00001349763,0.0002739494,0.00001616572,0.0008744183],"genre_scores_gemma":[0.9990952,0.0001871523,0.0003393075,0.0001076486,0.00002960053,0.000005061171,0.00008069949,0.00000540772,0.0001499353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003873869,"threshold_uncertainty_score":0.02048725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0136195384631499,"score_gpt":0.2586110272850121,"score_spread":0.2449914888218622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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