{"id":"W4284991426","doi":"10.1007/s10565-022-09745-x","title":"Transcriptional activation of budding yeast DDI2/3 through chemical modifications of Fzf1","year":2022,"lang":"en","type":"article","venue":"Cell Biology and Toxicology","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Methyl methanesulfonate; Saccharomyces cerevisiae; Chemistry; Biochemistry; Activator (genetics); Gene expression; Biology; Gene; Molecular biology; DNA; Cell biology; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001553401,0.0002954043,0.0001662517,0.000173155,0.0002178853,0.000279814,0.0003079333,0.0001998187,0.002070494],"category_scores_gemma":[0.0001374546,0.0001239767,0.0002765188,0.0001542607,0.0003111959,0.0001417522,0.0001994557,0.0004746495,0.0003860893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007055602,"about_ca_system_score_gemma":0.0002995372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002161137,"about_ca_topic_score_gemma":0.003323424,"domain_scores_codex":[0.9998726,0.00001257367,0.000008551216,0.00003101598,0.00003306244,0.00004227754],"domain_scores_gemma":[0.9999431,0.00001335336,0.00001423921,0.00001023667,0.000005678623,0.00001332315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002104746,0.00001453367,0.0001373815,0.0000249695,0.000004638643,0.00004351707,0.00001623405,0.0001037642,0.9981146,0.0003056634,0.00007235479,0.0009518907],"study_design_scores_gemma":[0.000006470308,0.0000151937,0.0005260865,0.000001148631,0.000002624936,0.00003193542,0.00001097097,0.0001673454,0.998349,0.00002185383,0.0008656261,0.000001836761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904796,0.001084302,0.003931694,0.0002451631,0.00006362932,0.00002168447,0.0009016195,0.0001518225,0.003120428],"genre_scores_gemma":[0.9959216,0.0002730432,0.001188382,0.00005669445,0.000005621155,0.00001174571,0.000600638,0.00003187269,0.001910386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002161137,"threshold_uncertainty_score":0.006926477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02421187736278628,"score_gpt":0.2878295006630489,"score_spread":0.2636176233002626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}