{"id":"W4284991848","doi":"10.1101/2022.07.08.499406","title":"SIR telomere silencing depends on nuclear envelope lipids and modulates sensitivity to a lysolipid drug","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates","keywords":"Biology; Gene silencing; Cell biology; Endoplasmic reticulum; Telomere; Proteostasis; Lysophosphatidylcholine; Biochemistry; Gene; Phosphatidylcholine; Phospholipid; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004526064,0.0005264244,0.0004219663,0.0001909546,0.000320052,0.0001453138,0.0002592949,0.0004096998,0.00008040682],"category_scores_gemma":[0.000169378,0.0005800824,0.0001358156,0.0002264149,0.00006718017,0.00000977713,0.001189213,0.000641297,0.00003136618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001203162,"about_ca_system_score_gemma":0.0001685256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007401916,"about_ca_topic_score_gemma":0.000008634662,"domain_scores_codex":[0.9974799,0.0001906771,0.000310008,0.00126405,0.0002969215,0.0004584784],"domain_scores_gemma":[0.9982985,0.00002471179,0.0001868698,0.001049245,0.0001571188,0.0002835917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001477721,0.00005004009,0.0016543,0.0001163281,0.0001315295,0.00002796289,0.00002906415,0.0005391146,0.9958814,0.0001259587,0.001265021,0.00003144256],"study_design_scores_gemma":[0.0007664725,0.0005081973,0.1342708,0.0002060651,0.0001632784,4.063191e-7,0.00004592336,0.0005244076,0.7710613,0.000003571852,0.09054261,0.001906927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974917,0.0002352126,0.00008604937,0.0002298404,0.0011742,0.0004287107,0.0001748683,0.0001267064,0.00005268244],"genre_scores_gemma":[0.995649,0.000161336,0.001982353,0.001000209,0.0009714564,0.00004512606,0.000001851965,0.0001671667,0.00002148139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2248202,"threshold_uncertainty_score":0.9996651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006218110223367611,"score_gpt":0.1974702719031187,"score_spread":0.1912521616797511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}