{"id":"W4284991848","doi":"10.1101/2022.07.08.499406","title":"SIR telomere silencing depends on nuclear envelope lipids and modulates sensitivity to a lysolipid drug","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates","keywords":"Biology; Gene silencing; Cell biology; Endoplasmic reticulum; Telomere; Proteostasis; Lysophosphatidylcholine; Biochemistry; Gene; Phosphatidylcholine; Phospholipid; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001061956,0.0002544566,0.0002629895,0.0001419915,0.0001111704,0.0002705044,0.0001298746,0.0002090102,0.002602187],"category_scores_gemma":[0.00007487064,0.0000969777,0.0002560333,0.0001591855,0.0001287303,0.0001562943,0.0001699516,0.0005989042,0.00054734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002200436,"about_ca_system_score_gemma":0.0001223238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003641826,"about_ca_topic_score_gemma":0.0004730839,"domain_scores_codex":[0.9999173,0.000009149318,0.000005238031,0.00002026756,0.00003047348,0.00001754513],"domain_scores_gemma":[0.9999429,0.000006852691,0.00002213787,0.000004941403,0.00001065428,0.00001251083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001049878,0.000009015193,0.0002258698,0.00006450648,0.000008096858,0.00003812895,0.000009416305,0.00009165476,0.9975339,0.00009150943,0.0001751715,0.001647643],"study_design_scores_gemma":[0.00001298235,0.0001053948,0.005111021,0.000009667592,0.00001640065,0.00007666114,0.00002940829,0.001184031,0.9901069,0.00009224015,0.003248769,0.000006418801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780458,0.005130588,0.007790933,0.000561816,0.0001155278,0.0000449246,0.003878981,0.0003944769,0.004036832],"genre_scores_gemma":[0.9893357,0.002208026,0.002032068,0.0001118512,0.0000156955,0.00003358323,0.002128055,0.00003906002,0.004095933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002602187,"threshold_uncertainty_score":0.008705199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006218110223367611,"score_gpt":0.1974702719031187,"score_spread":0.1912521616797511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}