{"id":"W4284994282","doi":"10.1101/2022.07.05.498916","title":"Validated Preclinical Murine Model for Therapeutic Testing against Multidrug Resistant <i>Pseudomonas aeruginosa</i>","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hamilton Health Sciences Foundation","keywords":"Pseudomonas aeruginosa; Acinetobacter baumannii; Enterococcus faecium; Antimicrobial; Antibiotics; Microbiology; Antibiotic resistance; Aztreonam; Multiple drug resistance; Biology; Medicine; Bacteria; Imipenem","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001215888,0.001311654,0.0006495967,0.0009900513,0.0003479462,0.000843144,0.001039033,0.001197882,0.002199643],"category_scores_gemma":[0.0005292153,0.0003726585,0.0008720343,0.0003018519,0.0005677858,0.00101303,0.000424872,0.002555828,0.001109736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007904747,"about_ca_system_score_gemma":0.0007271681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008444863,"about_ca_topic_score_gemma":0.001190927,"domain_scores_codex":[0.99914,0.0001985133,0.00008527598,0.0001490547,0.0002390919,0.0001880332],"domain_scores_gemma":[0.9989508,0.0001468975,0.0003339758,0.0002117596,0.0001668597,0.0001895923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005943928,0.001382808,0.0005145194,0.0001311864,0.00001735928,0.0001322208,0.0000339023,0.0008352725,0.9920333,0.0007306305,0.000502384,0.003091968],"study_design_scores_gemma":[0.0001279313,0.01298544,0.002470569,0.0000714098,0.00006545605,0.0005499364,0.00005928086,0.004593936,0.9713179,0.0003454564,0.007382472,0.00003030746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.889559,0.004374221,0.08342423,0.001328889,0.0007588827,0.001843771,0.006418596,0.002088597,0.01020384],"genre_scores_gemma":[0.9352928,0.002589885,0.0473058,0.0006694095,0.0001211123,0.001607527,0.004331585,0.0002191003,0.007862872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002199643,"threshold_uncertainty_score":0.007358551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03723313772667314,"score_gpt":0.2762415264596201,"score_spread":0.239008388732947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}