{"id":"W4285008973","doi":"10.1111/pcmr.13054","title":"<scp>NR2F1</scp> regulates a Schwann cell precursor‐vs‐melanocyte cell fate switch in a mouse model of Waardenburg syndrome type <scp>IV</scp>","year":2022,"lang":"en","type":"article","venue":"Pigment Cell & Melanoma Research","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Microphthalmia-associated transcription factor; Downregulation and upregulation; Neural crest; Cell biology; Melanocyte; Cell fate determination; Neuroscience; Transcription factor; Cancer research; Genetics; Embryo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002236143,0.0005986739,0.00035273,0.0007705189,0.0003110589,0.000427512,0.0004017521,0.0007780585,0.002005052],"category_scores_gemma":[0.0001285981,0.0003625733,0.0005028167,0.000202341,0.000706883,0.000273416,0.0002683255,0.001266072,0.0006635566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005355804,"about_ca_system_score_gemma":0.0003553109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002210528,"about_ca_topic_score_gemma":0.004170506,"domain_scores_codex":[0.9995802,0.0000694884,0.00004399195,0.0001032525,0.0001161883,0.0000869249],"domain_scores_gemma":[0.999651,0.0000366005,0.0001149716,0.00003063241,0.00002082254,0.0001460085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001597996,0.00004474715,0.0001535493,0.00001691318,0.000004938486,0.0001274598,0.00002101838,0.00006228603,0.9989647,0.00008925935,0.00003441035,0.0003210281],"study_design_scores_gemma":[0.00008579309,0.0006288405,0.008101167,0.0000119176,0.00004364325,0.0006294615,0.000102223,0.001621075,0.9866198,0.00007471676,0.002067019,0.00001428707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996912,0.0004330199,0.001048273,0.0001031734,0.00003137299,0.00003318569,0.0004864103,0.00009773482,0.0008548697],"genre_scores_gemma":[0.9899158,0.0004580428,0.002216693,0.00008377023,0.00001492151,0.0001174935,0.0004985789,0.00008477087,0.006610108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002210528,"threshold_uncertainty_score":0.006707549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03088089827725371,"score_gpt":0.2861105050000229,"score_spread":0.2552296067227692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}