{"id":"W4285011397","doi":"10.1371/journal.pone.0271066","title":"Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer","year":2022,"lang":"en","type":"article","venue":"PLoS ONE","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Österreichischen Akademie der Wissenschaften; Canada Research Chairs; National Center for Advancing Translational Sciences; T. Von Zastrow Foundation; Leidos; Frederick National Laboratory for Cancer Research; Division of Cancer Prevention, National Cancer Institute","keywords":"Aerosolization; Tolerability; Nebulizer; Medicine; Pharmacology; Immunology; Virology; Inhalation; Adverse effect; Anesthesia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000879367,0.0004160126,0.0005819882,0.0002291252,0.000213012,0.0004399949,0.0004544972,0.0005318355,0.001441602],"category_scores_gemma":[0.0003471887,0.0001312584,0.0003999752,0.00008510375,0.0003485066,0.000500865,0.0002126974,0.0009825957,0.0002325941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002821535,"about_ca_system_score_gemma":0.0004321684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004486559,"about_ca_topic_score_gemma":0.0009483281,"domain_scores_codex":[0.9997305,0.0000727062,0.00001735969,0.00005038411,0.00008416309,0.00004487851],"domain_scores_gemma":[0.9998435,0.00003224253,0.0000392811,0.00001624683,0.00002452234,0.00004413095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.002225392,0.003199778,0.0007654812,0.0001880068,0.00005557423,0.0001634988,0.00006962351,0.0003698155,0.9598632,0.0001901789,0.0002899699,0.03261946],"study_design_scores_gemma":[0.001880384,0.1362033,0.01159366,0.00004108188,0.0002132684,0.0009798507,0.0001303078,0.005221255,0.8315074,0.0001965174,0.01200192,0.00003098369],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853592,0.001992532,0.009598108,0.0003194558,0.000125775,0.0008525998,0.0002616561,0.0001120415,0.001378551],"genre_scores_gemma":[0.9865069,0.001140289,0.009918391,0.0001993722,0.00005840156,0.0003247576,0.0003395345,0.00002182161,0.001490391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001441602,"threshold_uncertainty_score":0.004822612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1499823941203499,"score_gpt":0.3781567582821942,"score_spread":0.2281743641618443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}