{"id":"W4285011885","doi":"10.1164/rccm.202202-0392oc","title":"Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 Through 11 Years of Age with Cystic Fibrosis Heterozygous for <i>F508del</i> and a Minimal Function Mutation: A Phase 3b, Randomized, Placebo-controlled Study","year":2022,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"NIHR Imperial Biomedical Research Centre; Vertex Pharmaceuticals; Cystic Fibrosis Foundation Therapeutics; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Medicine; Cystic fibrosis; Ivacaftor; Placebo; Confidence interval; Regimen; Internal medicine; Gastroenterology; Randomized controlled trial; Pediatrics; Cystic fibrosis transmembrane conductance regulator; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002187846,0.001151105,0.003629809,0.0004936226,0.0004953442,0.0007554517,0.0008024413,0.001747682,0.002875219],"category_scores_gemma":[0.001658413,0.0006357094,0.001927104,0.0004009505,0.001131407,0.0008540485,0.0003563319,0.002597872,0.000489909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005052882,"about_ca_system_score_gemma":0.001121696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007472563,"about_ca_topic_score_gemma":0.001628476,"domain_scores_codex":[0.9986109,0.0006978334,0.0001319467,0.000213393,0.000189415,0.00015658],"domain_scores_gemma":[0.9981705,0.0003893034,0.0005564077,0.00007203744,0.000122802,0.0006889733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9495714,0.01571077,0.004626736,0.0006909191,0.00100139,0.0001078681,0.00006787328,0.0002205326,0.009653909,0.00004521081,0.0003742775,0.01792905],"study_design_scores_gemma":[0.7376702,0.2482831,0.01097097,0.00006298131,0.0008325276,0.0001139828,0.00003887686,0.0002095751,0.001291769,0.00003108185,0.0004756651,0.0000193366],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943359,0.003169955,0.000223183,0.0001672453,0.000096638,0.001101768,0.0003978007,0.00003196505,0.0004754],"genre_scores_gemma":[0.9931909,0.002204268,0.00103978,0.000459836,0.0002344183,0.001688911,0.0005244212,0.00001112354,0.0006463559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003629809,"threshold_uncertainty_score":0.01157057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0117619881525575,"score_gpt":0.3255101914860747,"score_spread":0.3137482033335172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}