{"id":"W4285011885","doi":"10.1164/rccm.202202-0392oc","title":"Efficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 Through 11 Years of Age with Cystic Fibrosis Heterozygous for <i>F508del</i> and a Minimal Function Mutation: A Phase 3b, Randomized, Placebo-controlled Study","year":2022,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"NIHR Imperial Biomedical Research Centre; Vertex Pharmaceuticals; Cystic Fibrosis Foundation Therapeutics; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Medicine; Cystic fibrosis; Ivacaftor; Placebo; Confidence interval; Regimen; Internal medicine; Gastroenterology; Randomized controlled trial; Pediatrics; Cystic fibrosis transmembrane conductance regulator; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001410084,0.0002143746,0.001882018,0.0003075926,0.0001069951,0.0000102594,0.00008971241,0.00003182997,0.00002903833],"category_scores_gemma":[0.002861729,0.0001556779,0.0001067059,0.0003419815,0.001865895,0.0001284325,0.00005878254,0.000346782,3.275277e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006584495,"about_ca_system_score_gemma":0.0001657996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007385519,"about_ca_topic_score_gemma":0.000002808491,"domain_scores_codex":[0.9969051,0.0006922901,0.001056954,0.0003015807,0.0007808179,0.0002632375],"domain_scores_gemma":[0.9952653,0.003529055,0.0004409173,0.000160414,0.0003501142,0.0002541848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9483945,0.0007901591,0.01689724,0.000405088,0.0004367059,0.0003421952,0.00144795,0.00002510253,0.003536815,0.0000700665,0.00003636703,0.02761776],"study_design_scores_gemma":[0.7724329,0.1390387,0.0495617,0.0007059184,0.00213069,0.0008794184,0.03438514,0.00006979248,0.0001320833,0.00006779224,0.0003659567,0.0002298432],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888899,0.007663618,0.001175694,0.0001330939,0.00001739142,0.002045456,0.00005880267,0.000006330883,0.000009765786],"genre_scores_gemma":[0.9980727,0.00005980316,0.001326596,0.0002392877,0.0001383408,0.0001284066,0.000007783467,0.00002429468,0.000002764511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1759616,"threshold_uncertainty_score":0.6874968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0117619881525575,"score_gpt":0.3255101914860747,"score_spread":0.3137482033335172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}