{"id":"W4285012124","doi":"10.1164/rccm.202110-2308oc","title":"Colocalization of Gene Expression and DNA Methylation with Genetic Risk Variants Supports Functional Roles of <i>MUC5B</i> and <i>DSP</i> in Idiopathic Pulmonary Fibrosis","year":2022,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Heart, Lung, and Blood Institute; Vertex Pharmaceuticals; U.S. Department of Veterans Affairs","keywords":"Expression quantitative trait loci; Genetics; Biology; DNA methylation; Quantitative trait locus; Methylation; Gene; Gene expression; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007056258,0.0002182088,0.0002172434,0.0008737943,0.0002068954,0.0003964744,0.0002955274,0.00031754,0.002738252],"category_scores_gemma":[0.001527838,0.0001571711,0.000403964,0.0004933545,0.0004212342,0.0001392145,0.0003708217,0.0002850903,0.0001553163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002716038,"about_ca_system_score_gemma":0.0002052866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004174666,"about_ca_topic_score_gemma":0.00416741,"domain_scores_codex":[0.9994198,0.0001337669,0.00004737015,0.0002461661,0.00008951361,0.00006334355],"domain_scores_gemma":[0.9990405,0.0003743359,0.0003497578,0.00008814668,0.00007212898,0.00007502731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001536925,0.00004042729,0.6193491,0.0001627858,0.0004910107,0.0005057561,0.0002264836,0.0006658622,0.3660081,0.0003446011,0.0002340857,0.01043471],"study_design_scores_gemma":[0.00003702754,0.0001485871,0.9798967,0.00002154744,0.0002530641,0.0007295468,0.0001179157,0.002281055,0.01581516,0.0003119785,0.000375488,0.00001207163],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996563,0.0004146014,0.001941198,0.00006559065,0.00000437632,0.000006447963,0.0005087424,0.00002977388,0.0004662779],"genre_scores_gemma":[0.999101,0.00003782591,0.0005783532,0.00002685223,0.000003309216,0.000004146654,0.0001445295,0.000005156237,0.00009880931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004174666,"threshold_uncertainty_score":0.00916034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007625325522540985,"score_gpt":0.2466600907616796,"score_spread":0.2390347652391386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}