{"id":"W4285013313","doi":"10.3389/fcell.2022.940197","title":"Enhancement of Chromatin and Epigenetic Reprogramming in Porcine SCNT Embryos—Progresses and Perspectives","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Mitacs; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Somatic cell nuclear transfer; Reprogramming; Cloning (programming); Biology; Epigenetics; Embryo; Chromatin; Somatic cell; Miniature pig; Cell biology; Genetics; Andrology; Blastocyst; Embryogenesis; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000384511,0.0001061237,0.0003134256,0.0001516184,0.00006661715,0.000002253117,0.00003388734,0.00005573588,0.00004505993],"category_scores_gemma":[0.0000605825,0.00009169528,0.00001236969,0.0001370179,0.0004016313,0.00001876706,0.0001640172,0.0001373822,2.195827e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007174379,"about_ca_system_score_gemma":0.00005046319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005601377,"about_ca_topic_score_gemma":0.000008229846,"domain_scores_codex":[0.9989852,0.00009458409,0.000263974,0.0004415651,0.00004445306,0.0001701785],"domain_scores_gemma":[0.9997661,0.00002669777,0.00006634588,0.00008237508,0.00001898523,0.00003946432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008582295,0.0002099742,0.9177095,0.00008873604,0.00002452669,0.00001377196,0.003042154,7.268275e-8,0.04391459,0.00001071049,0.00007721128,0.03405052],"study_design_scores_gemma":[0.001323092,0.0007145064,0.9427423,0.00002296052,0.00001031913,0.00005479919,0.0123628,0.0000149395,0.04122168,0.0004473542,0.0009693368,0.0001158698],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714859,0.02726785,0.00009067294,0.0002391273,0.0001127503,0.0003350669,0.00000405961,0.000005901948,0.0004587273],"genre_scores_gemma":[0.9831813,0.001216367,0.01531451,0.0000472658,0.0000101705,0.00005978867,0.00002279562,0.000004289066,0.000143517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03393465,"threshold_uncertainty_score":0.3739225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01438211074298639,"score_gpt":0.2493215630855544,"score_spread":0.234939452342568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}