{"id":"W4285013313","doi":"10.3389/fcell.2022.940197","title":"Enhancement of Chromatin and Epigenetic Reprogramming in Porcine SCNT Embryos—Progresses and Perspectives","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Mitacs; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Somatic cell nuclear transfer; Reprogramming; Cloning (programming); Biology; Epigenetics; Embryo; Chromatin; Somatic cell; Miniature pig; Cell biology; Genetics; Andrology; Blastocyst; Embryogenesis; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001331967,0.0002633684,0.0003827684,0.0003739828,0.0001302956,0.0008196099,0.0003117872,0.0004992123,0.00128622],"category_scores_gemma":[0.0003157224,0.0001028294,0.0003427643,0.0003414508,0.0004671675,0.0008489054,0.0004107287,0.0006260184,0.0002904708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002597908,"about_ca_system_score_gemma":0.0004652126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000247526,"about_ca_topic_score_gemma":0.0003476259,"domain_scores_codex":[0.9998203,0.00004771078,0.00001751942,0.00004668835,0.00003343789,0.00003435682],"domain_scores_gemma":[0.9997539,0.00009664565,0.00003410443,0.00002101686,0.00005307202,0.00004130069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007851132,0.000211923,0.005761685,0.007717784,0.0001223689,0.001499663,0.0008823434,0.001243722,0.3940104,0.01923394,0.00529399,0.5632372],"study_design_scores_gemma":[0.00008458237,0.002739158,0.03438651,0.002295806,0.000382528,0.004993173,0.001157035,0.002314489,0.2233531,0.01427226,0.7138994,0.0001218509],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05698033,0.9081779,0.01455231,0.003623931,0.0007845526,0.00005589921,0.0002521578,0.0001146424,0.01545834],"genre_scores_gemma":[0.2726529,0.7013682,0.01536029,0.002396684,0.001365158,0.000101344,0.0006534561,0.00006168138,0.006040211],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001331967,"threshold_uncertainty_score":0.007044196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01438211074298639,"score_gpt":0.2493215630855544,"score_spread":0.234939452342568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}