{"id":"W4285026337","doi":"10.15690/pf.v19i3.2438","title":"Clinical Case of Drug Allergy to Enzyme Replacement Therapy in a Patient with Mucopolysaccharidosis Type II","year":2022,"lang":"en","type":"article","venue":"Педиатрическая фармакология","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute","funders":"","keywords":"Enzyme replacement therapy; Hunter syndrome; Mucopolysaccharidosis type II; Medicine; Desensitization (medicine); Pharmacotherapy; Mucopolysaccharidosis; Drug; Disease; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002827349,0.001598141,0.00113198,0.001521259,0.002331011,0.0009939048,0.0007318287,0.003937828,0.00301135],"category_scores_gemma":[0.002291544,0.0007475954,0.0008589354,0.001142792,0.001418578,0.001281066,0.001287832,0.003409122,0.0005976554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001074471,"about_ca_system_score_gemma":0.00106401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002929693,"about_ca_topic_score_gemma":0.002630146,"domain_scores_codex":[0.9994755,0.00006447371,0.00005912576,0.0001646939,0.00006992677,0.0001662536],"domain_scores_gemma":[0.9988643,0.000301577,0.0002525092,0.00006157451,0.00007511043,0.0004448917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0000276115,0.00002155416,0.003732387,0.00001693389,0.000004466404,0.9949232,0.0001518475,0.00003031856,0.0003385773,0.00007169566,0.0002144139,0.0004670124],"study_design_scores_gemma":[0.00001072479,0.00005715257,0.002122231,0.000009861747,0.000006853598,0.9969004,0.0000683584,0.00007224039,0.000193289,0.0000544997,0.0004990147,0.000005197122],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9533235,0.01129716,0.004237615,0.007236839,0.0007313811,0.0003420935,0.0004504824,0.0002745876,0.02210629],"genre_scores_gemma":[0.9928738,0.001689381,0.0009729063,0.001702287,0.0004744244,0.00003192289,0.00009987893,0.00002598452,0.002129391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003937828,"threshold_uncertainty_score":0.01007396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03582924961173962,"score_gpt":0.3495306501282292,"score_spread":0.3137014005164896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}