{"id":"W4285032751","doi":"10.1038/s41598-022-15667-9","title":"Identification and validation of Alzheimer’s disease-related metabolic brain pattern in biomarker confirmed Alzheimer’s dementia patients","year":2022,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Javna Agencija za Raziskovalno Dejavnost RS; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Dementia; Biomarker; Medicine; Alzheimer's disease; Neuropsychology; Frontotemporal dementia; Disease; Internal medicine; Cohort; Oncology; Neuroimaging; Posterior cingulate; Pathology; Cognition; Psychology; Psychiatry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007829432,0.0004001416,0.0003630634,0.0008976635,0.0004196431,0.0005891625,0.0002822549,0.0004016552,0.0008385697],"category_scores_gemma":[0.00200106,0.0001826261,0.0002348665,0.0004459786,0.0002746062,0.0002472812,0.0003159817,0.0002189453,0.0002555231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002066247,"about_ca_system_score_gemma":0.000179869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001905137,"about_ca_topic_score_gemma":0.002165585,"domain_scores_codex":[0.9996554,0.00009125465,0.00005036567,0.0001025424,0.00005992382,0.00004049169],"domain_scores_gemma":[0.9993879,0.0001338829,0.0001717298,0.00007880823,0.0001579613,0.00006981023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008641392,0.0001018894,0.9835182,0.00003561441,0.00007200321,0.0008234876,0.0002417562,0.00007768946,0.01019539,0.00003205335,0.00009605461,0.003941671],"study_design_scores_gemma":[0.00002169683,0.0002728722,0.9948244,0.000007669453,0.00004163589,0.001940333,0.0001553133,0.0002837068,0.002152197,0.00004124806,0.0002535781,0.000005301457],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994606,0.0001411573,0.0001296213,0.000007795279,0.000003257278,0.000007940896,0.00008696689,0.000002572682,0.0001601789],"genre_scores_gemma":[0.9993937,0.00006141626,0.0002088942,0.00001220758,0.000004930007,0.000007987987,0.000227721,0.000001790709,0.00008142869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001905137,"threshold_uncertainty_score":0.004140615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03388770278158659,"score_gpt":0.3109508942557414,"score_spread":0.2770631914741548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}