{"id":"W4285033060","doi":"10.1016/j.bcp.2022.115168","title":"Treatment and prevention of pathological mitochondrial dysfunction in retinal degeneration and in photoreceptor injury","year":2022,"lang":"en","type":"review","venue":"Biochemical Pharmacology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Macular degeneration; Retinal degeneration; Medicine; Mitochondrion; Retina; Retinal; Population; Pathological; Glaucoma; Bioinformatics; Ophthalmology; Biology; Pathology; Neuroscience; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005420733,0.0009053641,0.001377931,0.002383762,0.0002871375,0.0006629988,0.001160281,0.001263674,0.003290451],"category_scores_gemma":[0.0005548624,0.0002527261,0.000693204,0.00150006,0.0004388093,0.0007703284,0.0005587989,0.002094709,0.001641486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005607241,"about_ca_system_score_gemma":0.0006020829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001032811,"about_ca_topic_score_gemma":0.002303661,"domain_scores_codex":[0.9998232,0.00003686817,0.00002495891,0.0000311299,0.00006440485,0.00001959145],"domain_scores_gemma":[0.9998271,0.00007314359,0.00002903613,0.000006790975,0.00004798951,0.0000159223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000141693,0.000223276,0.00009943405,0.01501282,0.0001436853,0.0002042468,0.00005676837,0.0003415133,0.002423666,0.002585551,0.01952875,0.9592385],"study_design_scores_gemma":[0.0001115141,0.0004282818,0.00171203,0.006048062,0.0002699762,0.002119338,0.00006929668,0.0002175481,0.001695815,0.002397493,0.984899,0.00003163219],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001771217,0.9985613,0.0001378879,0.0001497119,0.0001702432,0.000009704574,0.00001738305,0.000008654771,0.0007679213],"genre_scores_gemma":[0.001054024,0.9977398,0.0002540882,0.0001634726,0.0001060049,0.00001424014,0.0000375869,0.000002173311,0.0006285153],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003290451,"threshold_uncertainty_score":0.01100761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03803520549577692,"score_gpt":0.3404355235338895,"score_spread":0.3024003180381125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}