{"id":"W4285034092","doi":"10.1002/mabi.202200174","title":"Stimuli‐Responsive Miktoarm Polymer‐Based Formulations for Fisetin Delivery and Regulatory Effects in Hyperactive Human Microglia","year":2022,"lang":"en","type":"article","venue":"Macromolecular Bioscience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Fisetin; Polymersome; Chemistry; Oxidative stress; Reactive oxygen species; Nanocarriers; Microglia; Biophysics; Drug delivery; Antioxidant; Cell biology; Nanotechnology; Pharmacology; Amphiphile; Biochemistry; Inflammation; Materials science; Polymer; Organic chemistry; Flavonoid; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003283004,0.0002000674,0.0001721535,0.0003873366,0.001105518,0.0001015964,0.0003322764,0.0000379845,0.00004225913],"category_scores_gemma":[0.000419903,0.0002276976,0.00007635722,0.0006596359,0.0001662655,0.0001857729,0.0001966434,0.0001890407,0.000005166462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008578736,"about_ca_system_score_gemma":0.0001219763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001154365,"about_ca_topic_score_gemma":0.000007690024,"domain_scores_codex":[0.9976766,0.0004441119,0.0002825974,0.0007839849,0.0004421073,0.0003706626],"domain_scores_gemma":[0.9989213,0.0004496408,0.0001467939,0.0003188618,0.00004401716,0.0001194013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007189962,0.0000866827,0.00003692829,0.00001583737,7.972594e-7,0.00007807135,0.000138586,0.0009452637,0.9914691,0.006775303,0.00006540382,0.0003161605],"study_design_scores_gemma":[0.001097037,0.0003384773,0.0007413473,0.000009073419,0.000007844391,0.00003280229,0.00003039985,0.02459989,0.9718542,0.0005798348,0.0004688054,0.0002403225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927161,0.00004436963,0.005096293,0.0006504022,0.0002670113,0.0009991972,0.00009851519,0.00007425361,0.0000538595],"genre_scores_gemma":[0.9944201,0.00000224918,0.001037746,0.003952986,0.00001865744,0.0002546557,0.0000131585,0.00002709206,0.000273408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02365463,"threshold_uncertainty_score":0.9285238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02181808576986689,"score_gpt":0.2731283097817922,"score_spread":0.2513102240119253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}