{"id":"W4285041350","doi":"10.1126/science.abq2679","title":"ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies","year":2022,"lang":"en","type":"article","venue":"Science","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":186,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Helmut Horten Stiftung; Eidgenössische Technische Hochschule Zürich; University of Washington; Vir Biotechnology; Fast Grants; Institute for Research in Biomedicine","keywords":"Virology; Coronavirus; Monoclonal antibody; Epitope; Biology; Glycoprotein; Antibody; Viral entry; Neutralizing antibody; Vero cell; Fusion protein; Epitope mapping; Virus; Molecular biology; Coronavirus disease 2019 (COVID-19); Immunology; Recombinant DNA; Gene; Viral replication; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001662165,0.0004437412,0.0002395121,0.0001566834,0.000102648,0.0002008294,0.0001834753,0.0002705668,0.0008076213],"category_scores_gemma":[0.0001629112,0.0001210092,0.000247095,0.00008273304,0.0001003156,0.0001309306,0.0001751654,0.0005106316,0.0002156073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002899214,"about_ca_system_score_gemma":0.0001143856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004998701,"about_ca_topic_score_gemma":0.0006946066,"domain_scores_codex":[0.9998513,0.0000254791,0.000007116788,0.0000260985,0.00003280473,0.00005708455],"domain_scores_gemma":[0.9999386,0.00001598216,0.000008629972,0.000008526144,0.00001328245,0.00001510679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004141502,0.00002976343,0.0002722548,0.000009351261,0.000005328182,0.0000284846,0.00000615294,0.00007219629,0.9987653,0.00003049003,0.00002570615,0.000713478],"study_design_scores_gemma":[0.00002479555,0.0004381412,0.005999229,0.000003909154,0.00002117335,0.0004876404,0.00001412092,0.002252065,0.9892823,0.0000388332,0.001434107,0.000003706468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960382,0.0004035795,0.00210538,0.00003503495,0.00001292348,0.0000230015,0.00007819468,0.00002896569,0.00127464],"genre_scores_gemma":[0.997005,0.0002184386,0.001377604,0.00008421861,0.00001250429,0.00001573376,0.0003149111,0.000006309875,0.0009653617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008076213,"threshold_uncertainty_score":0.002701759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1093727409099505,"score_gpt":0.4070737248550773,"score_spread":0.2977009839451268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}