{"id":"W4285041350","doi":"10.1126/science.abq2679","title":"ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies","year":2022,"lang":"en","type":"article","venue":"Science","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":186,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Helmut Horten Stiftung; Eidgenössische Technische Hochschule Zürich; University of Washington; Vir Biotechnology; Fast Grants; Institute for Research in Biomedicine","keywords":"Virology; Coronavirus; Monoclonal antibody; Epitope; Biology; Glycoprotein; Antibody; Viral entry; Neutralizing antibody; Vero cell; Fusion protein; Epitope mapping; Virus; Molecular biology; Coronavirus disease 2019 (COVID-19); Immunology; Recombinant DNA; Gene; Viral replication; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001587965,0.0001505916,0.0001920701,0.0003235844,0.001729593,0.0001561983,0.0008949877,0.00002364236,0.00002718489],"category_scores_gemma":[0.0003631917,0.0001077817,0.00007950322,0.001796778,0.000567371,0.0002513101,0.001055318,0.0003827501,0.0001662015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002991604,"about_ca_system_score_gemma":0.0005402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003618772,"about_ca_topic_score_gemma":0.00005543258,"domain_scores_codex":[0.9970379,0.00007713937,0.0002122066,0.0005403239,0.001436142,0.0006962307],"domain_scores_gemma":[0.9990857,0.0001405184,0.00005813961,0.000541666,0.0001201293,0.00005379826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008696513,0.00004635284,0.02009646,0.00001475881,0.000004634853,0.00007533599,0.002093178,0.000004580447,0.9709361,0.0002444902,0.000870356,0.005526801],"study_design_scores_gemma":[0.0003448176,0.0003534945,0.01986298,0.00004817564,0.00001201449,0.000146287,0.002852353,0.0002262898,0.7926416,0.0001104267,0.1832406,0.0001608763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915167,0.0003348604,0.00003452832,0.001428282,0.0003795718,0.0004737747,0.000008067875,0.00008508049,0.005739103],"genre_scores_gemma":[0.9641241,0.000006757492,0.0002287479,0.03527758,0.00009589159,0.00005680214,8.223217e-7,0.00001620431,0.0001930986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1823703,"threshold_uncertainty_score":0.99957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1093727409099505,"score_gpt":0.4070737248550773,"score_spread":0.2977009839451268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}