{"id":"W4285041382","doi":"10.1128/mbio.01687-22","title":"Cross-Kingdom Infection of Macrophages Reveals Pathogen- and Immune-Specific Global Reprogramming and Adaptation","year":2022,"lang":"en","type":"article","venue":"mBio","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bruker (Canada); University of Guelph","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Pathogen; Biology; Virulence; Microbiology; Immune system; Cryptococcus neoformans; Reprogramming; Adaptation (eye); Human pathogen; Cryptococcosis; Immunology; Bacteria; Cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002008515,0.000128279,0.0001697026,0.0002016147,0.0001331381,0.0003230168,0.0001019567,0.0002789869,0.001382894],"category_scores_gemma":[0.0001116159,0.0001051354,0.0001534487,0.0001118263,0.0002229799,0.000235473,0.0003991315,0.0004846428,0.0004393868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001136071,"about_ca_system_score_gemma":0.00009104187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001371782,"about_ca_topic_score_gemma":0.0003275215,"domain_scores_codex":[0.9998435,0.00003037085,0.000009597794,0.00003872809,0.00002290617,0.00005489631],"domain_scores_gemma":[0.9999278,0.00001003982,0.00001581928,0.00001683665,0.00001063589,0.00001892473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002210338,0.00002101079,0.002997559,0.0000328564,0.000006130921,0.0001484116,0.00009957861,0.00005348905,0.992452,0.0002771174,0.00006072327,0.00363008],"study_design_scores_gemma":[0.00003903506,0.001110903,0.2171789,0.00006788353,0.00005779089,0.003391164,0.001438237,0.002500549,0.7587226,0.001646439,0.01381814,0.00002834065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934865,0.002301129,0.002275589,0.00009690064,0.00002626068,0.00001080401,0.0001730486,0.00003070002,0.001599116],"genre_scores_gemma":[0.9967554,0.0005886268,0.0009604043,0.0001135033,0.000009128331,0.00001822828,0.000130229,0.00001011699,0.001414223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001382894,"threshold_uncertainty_score":0.004626215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03743960843048226,"score_gpt":0.3070375799937269,"score_spread":0.2695979715632447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}