{"id":"W4285043121","doi":"10.1093/jac/dkac221","title":"Evolution of β-lactamase-mediated cefiderocol resistance","year":2022,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Helse Nord RHF; Universitetet i Tromsø","keywords":"Ceftazidime; Biology; Siderophore; Cephalosporin; Microbiology; Pseudomonas aeruginosa; Gene; Genetics; Bacteria; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003564369,0.0001282692,0.0002637233,0.00009219933,0.00009030072,0.00001173093,0.0003337635,0.00007471509,0.0001341332],"category_scores_gemma":[0.0000658131,0.0001270386,0.0001905985,0.0001748177,0.00009774781,0.000008305922,0.00005442054,0.0001674091,0.000001176404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008706788,"about_ca_system_score_gemma":0.0002496199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004709149,"about_ca_topic_score_gemma":0.000006572531,"domain_scores_codex":[0.998809,0.00009925904,0.0005296,0.000154786,0.0002301245,0.0001772598],"domain_scores_gemma":[0.9987615,0.00002067454,0.0007534262,0.0002210887,0.0001947793,0.00004856727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001561044,0.000162578,0.005760424,0.00002567403,0.00007552626,0.000007507517,0.00005112562,0.00007882516,0.956622,0.00002214542,0.03555596,0.00007715547],"study_design_scores_gemma":[0.002685023,0.0005799539,0.01044402,0.00005288011,0.00002454573,0.0001343032,0.0001941242,0.000005970749,0.8713771,0.00008069748,0.1141876,0.000233821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970712,0.0003789626,0.001254845,0.0005076139,0.000316721,0.0001455761,0.00004275952,0.000003954035,0.0002783528],"genre_scores_gemma":[0.9960672,0.0002230603,0.002489483,0.0003939566,0.0002213625,0.000001168568,0.00001346349,0.00002824352,0.0005620485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08524494,"threshold_uncertainty_score":0.5180486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004974733322332276,"score_gpt":0.2241491140892433,"score_spread":0.219174380766911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}