{"id":"W4285043297","doi":"10.1111/all.15432","title":"Dupilumab significantly improves skin barrier function in patients with moderate‐to‐severe atopic dermatitis","year":2022,"lang":"en","type":"article","venue":"Allergy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"Sanofi","keywords":"Dupilumab; Atopic dermatitis; Transepidermal water loss; Eczema Area and Severity Index; Medicine; Stratum corneum; Ceramide; Dermatology; Atopy; Barrier function; Internal medicine; Immunology; Allergy; Gastroenterology; Pathology; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0000374244,0.0001240672,0.0002049989,0.0001281842,0.0001430848,0.00001038125,0.00007463853,0.00004368609,0.0009672553],"category_scores_gemma":[0.00002214838,0.0001111173,0.00003898092,0.0001894261,0.00002767111,0.00008678865,0.00006160208,0.0001599506,0.0000315145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006538038,"about_ca_system_score_gemma":0.0001043375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006564472,"about_ca_topic_score_gemma":0.0001001066,"domain_scores_codex":[0.9990261,0.00007299305,0.0001843869,0.000244723,0.0002455717,0.0002262913],"domain_scores_gemma":[0.9995384,0.00002549999,0.00004244673,0.0002169733,0.0000494426,0.000127247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005628371,0.001994651,0.868778,0.0001469863,0.0006157137,0.000529544,0.001801315,0.002087817,0.0001491646,0.001094991,0.103264,0.01390943],"study_design_scores_gemma":[0.003854781,0.0004127219,0.9779109,0.00001877828,0.00002658696,0.00002447521,0.0002298911,0.0002175629,0.00009045921,0.0002741223,0.01677905,0.0001606877],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964409,0.0001025487,0.00008052275,0.0005118533,0.0001631858,0.0003638697,0.00002363618,0.00004386847,0.00226961],"genre_scores_gemma":[0.9952204,0.00000379214,0.00005678551,0.003410095,0.0000237208,0.0001710596,0.0001579157,0.00001975982,0.0009364738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1091329,"threshold_uncertainty_score":0.999946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004745829800661572,"score_gpt":0.1981818931131493,"score_spread":0.1934360633124878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}