{"id":"W4285043297","doi":"10.1111/all.15432","title":"Dupilumab significantly improves skin barrier function in patients with moderate‐to‐severe atopic dermatitis","year":2022,"lang":"en","type":"article","venue":"Allergy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"Sanofi","keywords":"Dupilumab; Atopic dermatitis; Transepidermal water loss; Eczema Area and Severity Index; Medicine; Stratum corneum; Ceramide; Dermatology; Atopy; Barrier function; Internal medicine; Immunology; Allergy; Gastroenterology; Pathology; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001289567,0.0002905359,0.0004509477,0.0001095794,0.0001339217,0.0001804866,0.00009918658,0.0001429689,0.001188313],"category_scores_gemma":[0.0001685131,0.00005165354,0.0001992251,0.00007606366,0.00004503446,0.00009946049,0.00007573182,0.0003229053,0.0001698138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001265232,"about_ca_system_score_gemma":0.0001085638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002812178,"about_ca_topic_score_gemma":0.0007912461,"domain_scores_codex":[0.9999502,0.00001239423,0.000005139078,0.000009282702,0.0000102897,0.00001279633],"domain_scores_gemma":[0.9999223,0.00001550781,0.00001695666,0.000003609401,0.00001226219,0.00002939135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.04305436,0.005988238,0.1373911,0.001816417,0.001281857,0.00250932,0.0002718914,0.0006260326,0.3200314,0.0001323129,0.007390454,0.4795066],"study_design_scores_gemma":[0.003339037,0.04207723,0.883527,0.0001601393,0.001483803,0.008004664,0.0002468727,0.002252479,0.04135788,0.0001212318,0.01739319,0.00003636425],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918194,0.006354639,0.0001507303,0.0001149223,0.00004474028,0.00004394418,0.0001363004,0.00004941701,0.001285957],"genre_scores_gemma":[0.9982207,0.0008920109,0.0002126832,0.0001265838,0.00003032514,0.00001587548,0.0001512292,0.000002575295,0.0003479971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001188313,"threshold_uncertainty_score":0.003975272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004745829800661572,"score_gpt":0.1981818931131493,"score_spread":0.1934360633124878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}