{"id":"W4285046140","doi":"10.1016/j.mad.2022.111706","title":"Frailty and cytokines in preclinical models: Comparisons with humans","year":2022,"lang":"en","type":"review","venue":"Mechanisms of Ageing and Development","topic":"Frailty in Older Adults","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Chemokine; Inflammation; Cytokine; Immunology; Medicine; Proinflammatory cytokine; Tumor necrosis factor alpha; Ageing; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00145841,0.0008757339,0.002296207,0.001819274,0.0001485593,0.001038691,0.0006209053,0.0009353457,0.002298266],"category_scores_gemma":[0.001963218,0.0003021219,0.0008266467,0.001576139,0.0004111708,0.001014743,0.0006304816,0.001428233,0.0008017615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004527243,"about_ca_system_score_gemma":0.0009042792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006714663,"about_ca_topic_score_gemma":0.00125268,"domain_scores_codex":[0.9996002,0.0001067333,0.00009077953,0.00005226709,0.0001247468,0.00002520907],"domain_scores_gemma":[0.9989963,0.0006450705,0.000156713,0.00002806764,0.000137885,0.00003596657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005244331,0.0001450704,0.0004986296,0.07616521,0.000502768,0.0001303068,0.0001249357,0.0004066023,0.003552821,0.002236012,0.01185115,0.9038621],"study_design_scores_gemma":[0.0001846548,0.001163551,0.004913483,0.03751654,0.001449108,0.001636664,0.0001749723,0.0002219547,0.002157693,0.002715752,0.9478063,0.00005938599],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001533724,0.9993535,0.00005474208,0.00006782229,0.00006578522,0.000005807178,0.00002336,0.000002834834,0.0002727962],"genre_scores_gemma":[0.0009983315,0.998495,0.0001341459,0.0001160736,0.00006780035,0.0000223697,0.00003800029,0.000001217375,0.0001270708],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002298266,"threshold_uncertainty_score":0.007712901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1872693803527838,"score_gpt":0.3659830303377307,"score_spread":0.1787136499849468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}