{"id":"W4285081305","doi":"10.21203/rs.3.rs-15867/v1","title":"Muramyl dipeptide mediated immunomodulation on monocyte subsets exerts therapeutic effects in a mouse model of Alzheimer’s disease","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"","keywords":"Muramyl dipeptide; Monocyte; Genetically modified mouse; Microglia; Intravital microscopy; Receptor; Immunology; Flow cytometry; Amyloid precursor protein; CCR2; Internal medicine; Transgene; Inflammation; Endocrinology; Medicine; Pharmacology; Chemistry; Alzheimer's disease; Biochemistry; Disease; Immune system; Chemokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002633219,0.0006233158,0.000673722,0.0004803195,0.0002006141,0.0002667641,0.0002319245,0.000438056,0.001323615],"category_scores_gemma":[0.00008728108,0.0001760483,0.0003459601,0.0002068597,0.000201938,0.0002140632,0.0001710648,0.001233332,0.0004170714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001438497,"about_ca_system_score_gemma":0.0001847717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002802997,"about_ca_topic_score_gemma":0.0004856229,"domain_scores_codex":[0.9997485,0.00004546848,0.00002739564,0.00004055854,0.00005206598,0.00008594625],"domain_scores_gemma":[0.9998699,0.000007402629,0.00003030158,0.00001344881,0.00001920924,0.00005976243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001808773,0.0007758362,0.0002844433,0.0001122193,0.00001152626,0.0001297917,0.00003989146,0.00005534199,0.9920075,0.00007295723,0.0001876929,0.004514033],"study_design_scores_gemma":[0.000540941,0.01561706,0.01224173,0.00005117067,0.0001186024,0.0006540985,0.0001074818,0.001111179,0.9638248,0.0001406856,0.005570561,0.00002167356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931938,0.002775681,0.001407457,0.000210377,0.0001124894,0.000108329,0.0007231128,0.0001339479,0.001334804],"genre_scores_gemma":[0.9862992,0.002727262,0.003011023,0.0002288665,0.00007328916,0.0004279234,0.000939419,0.00002526304,0.006267783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001323615,"threshold_uncertainty_score":0.00442791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1830815203870134,"score_gpt":0.3841504185307493,"score_spread":0.2010688981437359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}