{"id":"W4285083739","doi":"10.3389/fviro.2022.956113","title":"Epigallocatechin Gallate and Isoquercetin Synergize With Remdesivir to Reduce SARS-CoV-2 Replication In Vitro","year":2022,"lang":"en","type":"article","venue":"Frontiers in Virology","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministère de l'Agriculture, des Pêcheries et de l'Alimentation; Université Laval; Centre hospitalier universitaire de Québec","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada First Research Excellence Fund","keywords":"Medicine; Virology; Coronavirus; Pharmacology; Population; In vitro; Pandemic; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Disease; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001485085,0.0001601435,0.0003002263,0.0005554803,0.00009605624,0.00003732539,0.0007336343,0.00005828982,0.000002274767],"category_scores_gemma":[0.000130962,0.000173364,0.00002383506,0.0009761741,0.0000784111,0.0002091763,0.0006177654,0.0003642051,0.000003066376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002599069,"about_ca_system_score_gemma":0.0001141924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001556595,"about_ca_topic_score_gemma":0.00005207185,"domain_scores_codex":[0.997409,0.0007975966,0.0003259323,0.0008916225,0.000232906,0.000342951],"domain_scores_gemma":[0.9989734,0.0001440229,0.0001055527,0.0007072953,0.00002323643,0.00004649335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.003249604,0.0005171272,0.01469016,0.00004669853,0.00007169745,0.0003792751,0.006288569,0.228902,0.4881103,0.02267455,0.01316491,0.2219051],"study_design_scores_gemma":[0.002649225,0.0009055781,0.1311571,0.00002808314,0.00001333385,0.0002987827,0.0002574264,0.7020251,0.06800231,0.0780756,0.01565021,0.0009372557],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6256108,0.0001174642,0.3694602,0.004005829,0.000260281,0.0002788799,0.00000293351,0.00004607759,0.0002174753],"genre_scores_gemma":[0.6801125,0.000007615271,0.3181039,0.001538934,0.00001372583,0.0001606757,0.000005676098,0.00001367407,0.00004323754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4731231,"threshold_uncertainty_score":0.7069579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0161420003689469,"score_gpt":0.2826106454553156,"score_spread":0.2664686450863686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}