{"id":"W4285087994","doi":"10.3389/fonc.2022.917961","title":"Neoadjuvant Chemoradiotherapy and Surgery for Esophageal Squamous Cell Carcinoma Versus Definitive Chemoradiotherapy With Salvage Surgery as Needed: The Study Protocol for the Randomized Controlled NEEDS Trial","year":2022,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; McGill University Health Centre; Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Vetenskapsrådet","keywords":"Medicine; Chemoradiotherapy; Randomized controlled trial; Esophageal squamous cell carcinoma; Salvage surgery; Esophageal cancer; Oncology; Surgery; Carcinoma; Radiation therapy; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03226925,0.006451971,0.01076162,0.001431178,0.002382605,0.003936596,0.003562844,0.007662963,0.05005589],"category_scores_gemma":[0.03640146,0.002078338,0.006144518,0.002239066,0.003936342,0.00319795,0.00250048,0.007129795,0.008033925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003695605,"about_ca_system_score_gemma":0.01081733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001594879,"about_ca_topic_score_gemma":0.00278214,"domain_scores_codex":[0.9712366,0.02113163,0.00218012,0.001897522,0.001707144,0.001846849],"domain_scores_gemma":[0.989066,0.00415838,0.002194055,0.001679542,0.001585827,0.001316185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.9676611,0.003997507,0.0003275188,0.006772224,0.001857641,0.00007990016,0.0001628139,0.0006873959,0.000614478,0.0019301,0.006656833,0.00925241],"study_design_scores_gemma":[0.9755947,0.00967314,0.0004476057,0.0008573164,0.0008202068,0.00002466054,0.00003993139,0.0007997883,0.0002383497,0.001283754,0.01018138,0.00003918745],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.008536814,0.001005923,0.002687583,0.0008201865,0.001308202,0.9804495,0.002846819,0.0001813551,0.002163619],"genre_scores_gemma":[0.004717352,0.0001986503,0.002517784,0.0002897661,0.00009281242,0.9909472,0.0003222365,0.00001270153,0.0009014793],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.05005589,"threshold_uncertainty_score":0.1706582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0369311212055253,"score_gpt":0.349210961442241,"score_spread":0.3122798402367156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}