{"id":"W4285087994","doi":"10.3389/fonc.2022.917961","title":"Neoadjuvant Chemoradiotherapy and Surgery for Esophageal Squamous Cell Carcinoma Versus Definitive Chemoradiotherapy With Salvage Surgery as Needed: The Study Protocol for the Randomized Controlled NEEDS Trial","year":2022,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; McGill University Health Centre; Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Vetenskapsrådet","keywords":"Medicine; Chemoradiotherapy; Randomized controlled trial; Esophageal squamous cell carcinoma; Salvage surgery; Esophageal cancer; Oncology; Surgery; Carcinoma; Radiation therapy; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004938988,0.0004236598,0.003330687,0.0004341458,0.0006062652,0.0000536344,0.000236434,0.0001175639,0.0001120111],"category_scores_gemma":[0.0007034455,0.0002200933,0.000676585,0.000463963,0.0005010667,0.00005700227,0.0000505536,0.0004887967,4.60232e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009863707,"about_ca_system_score_gemma":0.002071709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004356204,"about_ca_topic_score_gemma":0.00006029911,"domain_scores_codex":[0.9960088,0.001405675,0.0008147654,0.0005080249,0.0005217536,0.000740963],"domain_scores_gemma":[0.9783621,0.02041952,0.000464825,0.0004438545,0.0001376619,0.0001719885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.959359,0.002185533,0.007459129,0.00008704382,0.0009999507,0.0003336687,0.002931828,0.00002500277,0.000003630549,0.00003044706,0.01941315,0.007171568],"study_design_scores_gemma":[0.9610594,0.02225063,0.0003602313,0.000007669622,0.0005193224,0.0000537468,0.009419853,0.0008993368,0.000139288,0.0001263161,0.004956765,0.0002074375],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.2319569,0.007325803,0.001167009,0.007761479,0.001654685,0.7496796,0.00005583986,0.00006166307,0.0003370067],"genre_scores_gemma":[0.4338502,0.00004164945,0.000386398,0.000927186,0.0003553263,0.5639586,0.00002112499,0.00005877534,0.0004007795],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.2018933,"threshold_uncertainty_score":0.8975144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0369311212055253,"score_gpt":0.349210961442241,"score_spread":0.3122798402367156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}