{"id":"W4285088765","doi":"10.3390/molecules27144446","title":"Hit Compounds and Associated Targets in Intracellular Mycobacterium tuberculosis","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; British Columbia Lung Association","keywords":"Mycobacterium tuberculosis; Tuberculosis; Drug resistance; Nonsynonymous substitution; Biology; rpoB; Drug discovery; Genome; Drug; Extensively drug-resistant tuberculosis; Gene; Computational biology; Genetics; Multiple drug resistance; Medicine; Bioinformatics; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001182416,0.000218843,0.0003998593,0.000644448,0.000190395,0.0003739371,0.0001786598,0.0004352317,0.0008517182],"category_scores_gemma":[0.0003481853,0.0001264711,0.0002129545,0.000918145,0.0001955611,0.0002257192,0.0002529535,0.0002372373,0.0002110786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002383382,"about_ca_system_score_gemma":0.000185802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009402726,"about_ca_topic_score_gemma":0.0009499391,"domain_scores_codex":[0.9998558,0.00001778939,0.00001195057,0.00003683831,0.00005979995,0.00001783043],"domain_scores_gemma":[0.9998117,0.00004278039,0.00009274935,0.0000153812,0.00002309844,0.00001435409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003803594,0.00008676449,0.03676463,0.0004107257,0.00006294092,0.001152031,0.0001528474,0.001390839,0.9223483,0.0006233357,0.0002096308,0.03641773],"study_design_scores_gemma":[0.00006696174,0.001928726,0.3979923,0.0001252955,0.0004371208,0.01107469,0.0005490619,0.004906034,0.5633268,0.002123378,0.01743086,0.00003870015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867498,0.008824576,0.001453476,0.0001580531,0.000006644347,0.00001656122,0.001143808,0.00006290972,0.001584208],"genre_scores_gemma":[0.9951846,0.001987779,0.001390597,0.00008069255,0.000005811403,0.000008589205,0.0008921337,0.00001203151,0.0004377075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009402726,"threshold_uncertainty_score":0.002849281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01545484430714135,"score_gpt":0.2740701636226228,"score_spread":0.2586153193154814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}