{"id":"W4285090011","doi":"10.3390/pharmaceutics14071452","title":"Brain Delivery of IGF1R5, a Single-Domain Antibody Targeting Insulin-like Growth Factor-1 Receptor","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Blood–brain barrier; Transcytosis; In vivo; Pharmacology; Receptor; Drug delivery; Chemistry; Cell biology; Biophysics; Biology; Internal medicine; Central nervous system; Endocrinology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001992567,0.0002063205,0.0002644999,0.0001100275,0.0003320002,0.00002289563,0.0005028583,0.00003094391,0.0005652743],"category_scores_gemma":[0.0002600827,0.0002140295,0.0001246269,0.0004760923,0.0001600522,0.0001384894,0.0006030552,0.0004827385,0.00004897192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006246633,"about_ca_system_score_gemma":0.00004970979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000137591,"about_ca_topic_score_gemma":2.969896e-7,"domain_scores_codex":[0.9977717,0.0005318655,0.0003915045,0.0004810682,0.0003749724,0.0004488505],"domain_scores_gemma":[0.9988733,0.000528391,0.0002446106,0.0001798211,0.00005318386,0.0001207271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001729155,0.0003179358,0.0004084925,0.00004449204,0.000008147425,0.0000386723,0.0003506542,0.00009177258,0.9945245,0.0008286564,0.002408323,0.0008054829],"study_design_scores_gemma":[0.000670731,0.0003765214,0.000123069,0.000007170264,0.000009721925,0.00001734621,0.000146368,0.0005533739,0.8022707,0.0003481473,0.1952363,0.0002406159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972963,0.0001470481,0.00002826173,0.0004088362,0.0007825255,0.0002231641,0.0002227851,0.00009932206,0.000791733],"genre_scores_gemma":[0.9934756,0.0001761754,0.0002877389,0.00571234,0.0001350219,0.000009940736,0.00001778969,0.00004899564,0.0001364661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.192828,"threshold_uncertainty_score":0.8727868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07142232288898082,"score_gpt":0.3242077955547102,"score_spread":0.2527854726657294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}