{"id":"W4285090011","doi":"10.3390/pharmaceutics14071452","title":"Brain Delivery of IGF1R5, a Single-Domain Antibody Targeting Insulin-like Growth Factor-1 Receptor","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Blood–brain barrier; Transcytosis; In vivo; Pharmacology; Receptor; Drug delivery; Chemistry; Cell biology; Biophysics; Biology; Internal medicine; Central nervous system; Endocrinology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001131354,0.0003025335,0.0002432481,0.0001457712,0.0001042498,0.0001836937,0.0001956601,0.0002639793,0.0004125491],"category_scores_gemma":[0.00007303512,0.00006084245,0.0002084495,0.00007819786,0.0001499395,0.0001812846,0.0001079154,0.0004425329,0.000111867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004566238,"about_ca_system_score_gemma":0.0002134133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001733838,"about_ca_topic_score_gemma":0.001754245,"domain_scores_codex":[0.9999182,0.000009307501,0.000005118849,0.00001948746,0.00001913356,0.0000286439],"domain_scores_gemma":[0.9999747,0.000004061515,0.000007668054,0.000002309737,0.000004601615,0.000006653162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000730137,0.00002920337,0.00009222519,0.00004449226,0.000006389108,0.00003016826,0.0000118667,0.0001029641,0.9970564,0.00007540327,0.00003558872,0.002442401],"study_design_scores_gemma":[0.00001052118,0.0006924543,0.001248746,0.00000353238,0.0000217317,0.0001337604,0.00001351819,0.00103266,0.9956045,0.00001435314,0.001220757,0.000003509567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941907,0.001824832,0.003179332,0.00006549713,0.00002387102,0.00002882568,0.00009858714,0.00003353107,0.0005549476],"genre_scores_gemma":[0.9953591,0.0008524533,0.002791004,0.00003396157,0.000007048737,0.00001663824,0.0001521532,0.000004565765,0.0007831311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001733838,"threshold_uncertainty_score":0.003447473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07142232288898082,"score_gpt":0.3242077955547102,"score_spread":0.2527854726657294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}