{"id":"W4285090278","doi":"10.1152/physiol.00011.2022","title":"Noncytotoxic Roles of Granzymes in Health and Disease","year":2022,"lang":"en","type":"review","venue":"Physiology","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Collaboration On Repair Discoveries; Vancouver Coastal Health Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Eczema Society of Canada; Cancer Research Society; Mitacs; Government of Canada; Michael Smith Health Research BC; LEO Fondet; Rick Hansen Institute","keywords":"Granzyme; Proteases; Biology; Disease; Serine; Granzyme A; Granzyme B; Programmed cell death; Cell biology; Immunology; Immune system; Perforin; Apoptosis; Medicine; Genetics; Biochemistry; T cell; Enzyme; Pathology; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004903675,0.0007251619,0.001084435,0.001628864,0.0002452804,0.0009446343,0.0006980441,0.0008636107,0.002855938],"category_scores_gemma":[0.0006362379,0.0001612433,0.0003034533,0.001422188,0.0005616152,0.001125127,0.0008801999,0.001493713,0.001626623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004866574,"about_ca_system_score_gemma":0.0007694659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000399755,"about_ca_topic_score_gemma":0.0007842245,"domain_scores_codex":[0.9998623,0.00002573153,0.00002196575,0.00002267545,0.00005227985,0.00001501677],"domain_scores_gemma":[0.9997553,0.0001130517,0.00003421769,0.0000106041,0.0000549638,0.00003189381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008955297,0.00004764253,0.000141245,0.01181755,0.00007899586,0.0002117473,0.00005705007,0.0002816353,0.001762182,0.00490824,0.03040186,0.9502024],"study_design_scores_gemma":[0.0000166204,0.00006424014,0.0007447039,0.002781878,0.00007006391,0.001384033,0.0000439166,0.00006129194,0.000369248,0.003737605,0.990714,0.00001243562],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008061635,0.9988286,0.00007842392,0.0002082895,0.0001767054,0.000001802446,0.000008901941,0.000005222428,0.0006115037],"genre_scores_gemma":[0.0005584536,0.9986309,0.00007577775,0.0001223946,0.0002035195,0.000003238336,0.00001883906,0.000001155665,0.0003856173],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002855938,"threshold_uncertainty_score":0.009554029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07619659721251286,"score_gpt":0.3693754196893437,"score_spread":0.2931788224768309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}