{"id":"W4285090278","doi":"10.1152/physiol.00011.2022","title":"Noncytotoxic Roles of Granzymes in Health and Disease","year":2022,"lang":"en","type":"review","venue":"Physiology","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Collaboration On Repair Discoveries; Vancouver Coastal Health Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Eczema Society of Canada; Cancer Research Society; Mitacs; Government of Canada; Michael Smith Health Research BC; LEO Fondet; Rick Hansen Institute","keywords":"Granzyme; Proteases; Biology; Disease; Serine; Granzyme A; Granzyme B; Programmed cell death; Cell biology; Immunology; Immune system; Perforin; Apoptosis; Medicine; Genetics; Biochemistry; T cell; Enzyme; Pathology; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001128698,0.0001546958,0.001494642,0.0001759549,0.00002575682,0.000001102734,0.00006034512,0.00006591554,0.0002904234],"category_scores_gemma":[0.0000565406,0.000123943,0.000153712,0.0001644797,0.00004771389,0.00001061198,0.00007217025,0.0001998153,0.000004289311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003276651,"about_ca_system_score_gemma":0.0004185425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001293008,"about_ca_topic_score_gemma":0.000003372239,"domain_scores_codex":[0.9988773,0.0002433211,0.0004001351,0.000251662,0.00008334726,0.0001441891],"domain_scores_gemma":[0.9992781,0.00009029439,0.0002269344,0.0002172228,0.000007293675,0.0001801607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006677604,0.000397872,0.00002231047,0.05678168,0.0001291317,0.00001006628,0.0001534294,6.157371e-7,0.0000571873,0.01138567,0.0001651912,0.9308301],"study_design_scores_gemma":[0.0005014859,0.0003562059,0.0002964553,0.0035946,0.0001805337,0.00001114542,0.00003254453,0.0000107065,0.000001803995,0.002249767,0.9926411,0.0001236499],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001830851,0.9989638,0.000001938945,0.0001548376,0.00007226311,0.0005114977,0.00002506926,0.00001429083,0.00007325058],"genre_scores_gemma":[0.001587965,0.9975774,0.00003926943,0.0003739343,0.0000401428,0.0000955912,0.0002215703,0.00002031584,0.00004380578],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9924759,"threshold_uncertainty_score":0.505425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07619659721251286,"score_gpt":0.3693754196893437,"score_spread":0.2931788224768309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}