{"id":"W4285091267","doi":"10.21203/rs.3.rs-1188756/v2","title":"A target engagement assay to assess uptake, potency and retention of antibiotics in living bacteria","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; McGill University","funders":"Empresa Brasileira de Pesquisa e Inovação Industrial; Universidade Estadual de Campinas; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo; Cystic Fibrosis Canada","keywords":"Antibiotics; Bacteria; Efflux; Antimicrobial; Bacterial cell structure; Pathogenic bacteria; Escherichia coli; Microbiology; Dihydrofolate reductase; Biology; Antibiotic resistance; Biochemistry; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008080401,0.001269322,0.001142408,0.0006605964,0.0003823455,0.001033794,0.0008727991,0.00153256,0.002691401],"category_scores_gemma":[0.0009156321,0.0005053125,0.0005717904,0.0007182977,0.0004228462,0.0006917004,0.001091632,0.001574462,0.002569873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00040957,"about_ca_system_score_gemma":0.0002917236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005687363,"about_ca_topic_score_gemma":0.0006926255,"domain_scores_codex":[0.9983543,0.0003430509,0.00008611679,0.0003361489,0.0006945612,0.0001858332],"domain_scores_gemma":[0.9993039,0.0003243514,0.00007547976,0.0001085003,0.0001213024,0.00006645989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004900924,0.0000453738,0.0000862174,0.00005435268,0.000006724598,0.00001425157,0.00002371677,0.0001108144,0.9973773,0.0001211779,0.0000905747,0.002020522],"study_design_scores_gemma":[0.000008825371,0.000285958,0.0005555041,0.000006418042,0.00001462943,0.0000972643,0.00001782318,0.001937437,0.9957685,0.0000896722,0.001206861,0.00001111604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6020554,0.004662857,0.3703668,0.0004886753,0.0002462586,0.0006664498,0.003315721,0.002362832,0.01583494],"genre_scores_gemma":[0.8418403,0.003001964,0.1119018,0.0003241894,0.00008676415,0.0008612882,0.005371823,0.0004584701,0.03615347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002691401,"threshold_uncertainty_score":0.00900358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08192206952206856,"score_gpt":0.3842505593278047,"score_spread":0.3023284898057361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}