{"id":"W4285094368","doi":"10.1007/s00441-022-03669-y","title":"Cholesterol and its reciprocal association with prion infection","year":2022,"lang":"en","type":"review","venue":"Cell and Tissue Research","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Alberta Prion Research Institute; Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Lipid raft; Cholesterol; Biology; Pathogenesis; Prion protein; In vivo; Disease; Virology; Cell biology; Homeostasis; Lipid metabolism; Neuroscience; Immunology; Biochemistry; Medicine; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006959832,0.001118874,0.001669981,0.002407985,0.0003104208,0.001377351,0.000837141,0.001686905,0.001575915],"category_scores_gemma":[0.0008426351,0.0003672311,0.0003343028,0.002710971,0.0009633183,0.001193626,0.0008792731,0.002333774,0.001361703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001087707,"about_ca_system_score_gemma":0.001122873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00176576,"about_ca_topic_score_gemma":0.002857155,"domain_scores_codex":[0.9998133,0.00003559742,0.00002822163,0.00003315571,0.0000693422,0.00002045399],"domain_scores_gemma":[0.9997216,0.000149579,0.00003043661,0.00001153649,0.000060954,0.00002603719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002773767,0.0001007204,0.0002761299,0.01132999,0.0001271266,0.0005798325,0.00006241407,0.0004746684,0.003252034,0.009057592,0.05075818,0.9237039],"study_design_scores_gemma":[0.00005319022,0.00008650692,0.001106655,0.002609262,0.0001828631,0.001761641,0.00005502592,0.0001374259,0.001353824,0.00476472,0.9878565,0.00003241656],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000776161,0.9989657,0.00007921444,0.0001938051,0.0001885811,0.000002331615,0.0000115305,0.000003855293,0.0004772696],"genre_scores_gemma":[0.0005658672,0.9984518,0.00009637178,0.0001720999,0.0002813364,0.000006436465,0.00002198383,0.000001024443,0.0004029814],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002407985,"threshold_uncertainty_score":0.007891953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07478822716453702,"score_gpt":0.3914286041648762,"score_spread":0.3166403770003391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}