{"id":"W4285095687","doi":"10.3233/jad-220024","title":"Does Loss of Integrity of the Cingulum Bundle Link Amyloid-β Accumulation and Neurodegeneration in Alzheimer’s Disease?","year":2022,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; ZonMw; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"Neurodegeneration; Cingulum (brain); Neuroscience; Disease; Amyloid (mycology); Medicine; Pathology; Psychology; Diffusion MRI; Fractional anisotropy; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00474942,0.0007610962,0.0006104643,0.001103255,0.0007444914,0.0009521332,0.0006932562,0.0009699556,0.002722114],"category_scores_gemma":[0.01630039,0.0004261417,0.001233866,0.0008430828,0.00100175,0.000657841,0.0008502517,0.0005959623,0.0002776098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004740192,"about_ca_system_score_gemma":0.0004980206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008736889,"about_ca_topic_score_gemma":0.01199449,"domain_scores_codex":[0.9987569,0.0005618071,0.00009735831,0.0002736665,0.0001606253,0.0001496155],"domain_scores_gemma":[0.9943821,0.002893374,0.001292718,0.0007929269,0.0003725671,0.0002662663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00285658,0.00006890279,0.98025,0.0001279654,0.001901091,0.0003606576,0.0002393065,0.000604409,0.002744374,0.0001710038,0.0003055909,0.01037009],"study_design_scores_gemma":[0.00004156908,0.0003339671,0.9953361,0.0000314272,0.0007969962,0.0005069998,0.0001012989,0.001196689,0.0005679997,0.0006021984,0.0004697101,0.00001503228],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962901,0.002185242,0.0004416743,0.0002194068,0.0000315426,0.00001741984,0.000149981,0.00001474434,0.0006497856],"genre_scores_gemma":[0.9992129,0.0002036375,0.0002789145,0.00005700231,0.00002264681,0.000009793541,0.0001561014,0.000004041288,0.00005505576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008736889,"threshold_uncertainty_score":0.02511764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04410696741480244,"score_gpt":0.3391238074604263,"score_spread":0.2950168400456238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}