{"id":"W4285097479","doi":"10.1016/j.celrep.2022.111070","title":"Ubiquitination and deubiquitination of 4E-T regulate neural progenitor cell maintenance and neurogenesis by controlling P-body formation","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Cumming School of Medicine, University of Calgary; Alberta Children's Hospital Research Institute; Natural Sciences and Engineering Research Council of Canada; Wuhan University; Azrieli Foundation; Canadian Institutes of Health Research; Mitacs; Canada Research Chairs","keywords":"Neurogenesis; Ubiquitin; Cell biology; Ubiquitin ligase; Neural stem cell; Deubiquitinating enzyme; Progenitor cell; Biology; Cellular differentiation; Stem cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001264461,0.0003124853,0.0002085044,0.0002660146,0.0002056932,0.0004404553,0.0001762557,0.0002344215,0.0005772205],"category_scores_gemma":[0.0001503146,0.0001480395,0.0001854739,0.0001364605,0.000351139,0.0003203829,0.0003067857,0.0002379808,0.000176702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003350999,"about_ca_system_score_gemma":0.0002311547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000469371,"about_ca_topic_score_gemma":0.0009096638,"domain_scores_codex":[0.9998915,0.00001817563,0.0000100296,0.00002948342,0.00001959761,0.00003128489],"domain_scores_gemma":[0.999881,0.00001065167,0.00005717298,0.00001198687,0.00001030462,0.00002886167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001169103,0.000009331491,0.001101507,0.00002209492,0.000005382584,0.00007198782,0.00001121977,0.0001103414,0.9968592,0.000200573,0.00001829907,0.001473127],"study_design_scores_gemma":[0.000008741337,0.0000605818,0.01028513,0.000003464433,0.00001087264,0.0002358023,0.00002448615,0.0008964414,0.9874286,0.0001196994,0.0009216942,0.000004519507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939389,0.002183509,0.002970662,0.00004714219,0.00001129936,0.000008714052,0.0001157682,0.00004534321,0.0006787217],"genre_scores_gemma":[0.9963887,0.0008806664,0.001476259,0.00001611515,0.000003703165,0.000009447558,0.0001030624,0.000009930695,0.001112281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005772205,"threshold_uncertainty_score":0.002431333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005699840703521721,"score_gpt":0.2024850301491659,"score_spread":0.1967851894456441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}