{"id":"W4285098558","doi":"10.1002/cpz1.483","title":"Receptor Interactome Discovery with RDIMIS, a Membrane Protein Interaction Screen Using Recombinant Extracellular Vesicles","year":2022,"lang":"en","type":"article","venue":"Current Protocols","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Microsemi (Canada)","funders":"","keywords":"Extracellular vesicles; Vesicle; Transmembrane protein; Extracellular; Membrane protein; Membrane; Cell biology; Interactome; G protein-coupled receptor; Computational biology; Biology; Chemistry; Receptor; Biochemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002203256,0.001144627,0.001271733,0.001647087,0.0008714474,0.001719965,0.001059716,0.0008651039,0.007400138],"category_scores_gemma":[0.002226571,0.0009522847,0.001081494,0.0007649762,0.0004948294,0.0008401701,0.001778921,0.001572273,0.005708616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006691326,"about_ca_system_score_gemma":0.0008962145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005507649,"about_ca_topic_score_gemma":0.001603479,"domain_scores_codex":[0.9975267,0.0005036949,0.0002244679,0.0003082706,0.001220789,0.0002160499],"domain_scores_gemma":[0.9986896,0.0004609872,0.0001634596,0.0002789676,0.0002686128,0.0001383836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000169941,0.00008584145,0.0005496672,0.0002134955,0.00005222192,0.0001870426,0.00005890161,0.0003080428,0.9824715,0.001183772,0.002843092,0.01187649],"study_design_scores_gemma":[0.00002771905,0.0001466507,0.0009745863,0.00001813569,0.00002796877,0.0003287332,0.00002512777,0.002129129,0.9802567,0.0001858388,0.01585537,0.00002407001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3090396,0.003129177,0.6063899,0.00134425,0.0003601077,0.005101028,0.02748067,0.01816805,0.02898725],"genre_scores_gemma":[0.3286102,0.003781565,0.582982,0.0007889795,0.00006816393,0.005447848,0.03807414,0.002728855,0.03751826],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.007400138,"threshold_uncertainty_score":0.0247559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03519958388917983,"score_gpt":0.3200221111403382,"score_spread":0.2848225272511584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}