{"id":"W4285098558","doi":"10.1002/cpz1.483","title":"Receptor Interactome Discovery with RDIMIS, a Membrane Protein Interaction Screen Using Recombinant Extracellular Vesicles","year":2022,"lang":"en","type":"article","venue":"Current Protocols","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Microsemi (Canada)","funders":"","keywords":"Extracellular vesicles; Vesicle; Transmembrane protein; Extracellular; Membrane protein; Membrane; Cell biology; Interactome; G protein-coupled receptor; Computational biology; Biology; Chemistry; Receptor; Biochemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004164758,0.0003349024,0.0002557645,0.0001072162,0.0003204599,0.0001553308,0.0005079159,0.00006740628,0.0002363077],"category_scores_gemma":[0.00007132105,0.0003146925,0.0001636467,0.0002265249,0.0001047572,0.00006385615,0.0005126036,0.0004376541,0.00001458866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001574146,"about_ca_system_score_gemma":0.0002395172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001450774,"about_ca_topic_score_gemma":0.000003511057,"domain_scores_codex":[0.9975975,0.0003685631,0.0004529183,0.000734574,0.0004174518,0.0004290569],"domain_scores_gemma":[0.9986425,0.00001362786,0.000366142,0.0007330044,0.00008546451,0.0001592595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001655719,0.0008791786,0.0008338824,0.0001902714,0.00006375332,0.00001852592,0.00006015776,0.0003712523,0.9883574,0.0001097716,0.0006462797,0.006813762],"study_design_scores_gemma":[0.001877031,0.0011257,0.000101805,0.0004609349,0.00003960908,0.00006434335,0.0002167987,0.0006118079,0.753441,0.00007984608,0.2413525,0.0006286569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9515432,0.0008087922,0.004890878,0.00007999942,0.0003248253,0.04209714,0.000110108,0.00005520297,0.00008985458],"genre_scores_gemma":[0.910479,0.00001126464,0.001914892,0.00003888721,0.0003421635,0.08550578,0.0006040253,0.0001151084,0.0009888664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2407062,"threshold_uncertainty_score":0.9999305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03519958388917983,"score_gpt":0.3200221111403382,"score_spread":0.2848225272511584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}