{"id":"W4285106091","doi":"10.7150/thno.72269","title":"Blockade of phosphotyrosine pathways suggesting SH2 superbinder as a novel therapy for pulmonary fibrosis","year":2022,"lang":"en","type":"article","venue":"Theranostics","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Huazhong University of Science and Technology; China Postdoctoral Science Foundation; National Health Commission of the People's Republic of China; National Natural Science Foundation of China","keywords":"Nintedanib; Idiopathic pulmonary fibrosis; Pulmonary fibrosis; Bleomycin; Medicine; Cancer research; Lung; Fibrosis; Signal transduction; Pharmacology; Pathology; Internal medicine; Biology; Chemotherapy; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001317131,0.0002762079,0.0002352246,0.0003037184,0.0001184964,0.0001736479,0.0001673911,0.0001975976,0.001234129],"category_scores_gemma":[0.00005422107,0.00005936464,0.0002284657,0.0001521512,0.0001700006,0.0001722608,0.0001441503,0.0003991427,0.0001993342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001600561,"about_ca_system_score_gemma":0.0001419568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001197944,"about_ca_topic_score_gemma":0.0003068676,"domain_scores_codex":[0.9999524,0.00000571427,0.000004680252,0.00001132135,0.00001442941,0.00001148316],"domain_scores_gemma":[0.9999605,0.000005753907,0.00001595539,0.000002777985,0.000004632517,0.00001025119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001166714,0.0003827612,0.003344062,0.0004284717,0.0000600048,0.0003369669,0.00002710683,0.0002457125,0.9520757,0.0002400613,0.0006812017,0.04101119],"study_design_scores_gemma":[0.0007661236,0.008602058,0.07228158,0.0001046952,0.0004236723,0.006861956,0.00009017673,0.004105325,0.868679,0.0005878503,0.0374644,0.00003330569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9583027,0.03368987,0.004481118,0.0004455828,0.0001259771,0.000100634,0.0004703562,0.000169882,0.00221397],"genre_scores_gemma":[0.9794591,0.01312087,0.004059738,0.0002567986,0.0001160991,0.0001190549,0.0008985527,0.00001081648,0.001959051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001234129,"threshold_uncertainty_score":0.004128635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02613589019508664,"score_gpt":0.261151869481877,"score_spread":0.2350159792867903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}