{"id":"W4285190720","doi":"10.14283/jpad.2022.63","title":"Oral Tau Aggregation Inhibitor for Alzheimer's Disease: Design, Progress and Basis for Selection of the 16 mg/day Dose in a Phase 3, Randomized, Placebo-Controlled Trial of Hydromethylthionine Mesylate","year":2022,"lang":"en","type":"article","venue":"The Journal of Prevention of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Placebo; Biomarker; Medicine; Clinical trial; Internal medicine; Oncology; Atrophy; Pathology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01130811,0.00252416,0.004002885,0.0009879002,0.001132371,0.00166777,0.001304576,0.003510756,0.005317383],"category_scores_gemma":[0.006118659,0.001292108,0.002315844,0.0007184398,0.002252093,0.001911533,0.0008245968,0.002965058,0.001240466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001066923,"about_ca_system_score_gemma":0.003409746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007175182,"about_ca_topic_score_gemma":0.001681328,"domain_scores_codex":[0.9948621,0.003528823,0.0003490348,0.0004744207,0.0003107164,0.0004748661],"domain_scores_gemma":[0.9968302,0.0008099055,0.000769087,0.0002859379,0.0003176281,0.0009872562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9804066,0.009261579,0.0004284787,0.0002440203,0.0002240657,0.00001842115,0.00006981823,0.0001994821,0.00226863,0.0000887604,0.0003099603,0.006480184],"study_design_scores_gemma":[0.9365698,0.06202686,0.0005671304,0.00001351504,0.00009867714,0.000007205731,0.000008212432,0.0001298775,0.000233938,0.00007108092,0.0002636711,0.0000100798],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9022622,0.002955776,0.002935536,0.001295206,0.0009939977,0.08578207,0.001403626,0.0002127698,0.002158671],"genre_scores_gemma":[0.8709391,0.001723306,0.0135733,0.002240048,0.001147887,0.1058884,0.0009508371,0.00005415911,0.003482985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01130811,"threshold_uncertainty_score":0.05980366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03632448289961169,"score_gpt":0.3509823022406565,"score_spread":0.3146578193410448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}