{"id":"W4285190720","doi":"10.14283/jpad.2022.63","title":"Oral Tau Aggregation Inhibitor for Alzheimer's Disease: Design, Progress and Basis for Selection of the 16 mg/day Dose in a Phase 3, Randomized, Placebo-Controlled Trial of Hydromethylthionine Mesylate","year":2022,"lang":"en","type":"article","venue":"The Journal of Prevention of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Placebo; Biomarker; Medicine; Clinical trial; Internal medicine; Oncology; Atrophy; Pathology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005747901,0.0002587463,0.001211001,0.0004195855,0.0002236858,0.00001437196,0.0002184703,0.00005101298,0.0001185865],"category_scores_gemma":[0.00115188,0.0001555498,0.001095337,0.0004547327,0.0003462496,0.0002297633,0.00008704578,0.0002208682,1.991158e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000891104,"about_ca_system_score_gemma":0.001175979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001359734,"about_ca_topic_score_gemma":0.000002612441,"domain_scores_codex":[0.9944712,0.002487265,0.001547254,0.0002205987,0.0009861747,0.0002875319],"domain_scores_gemma":[0.995472,0.001144322,0.002121731,0.0002946049,0.0006024039,0.0003649053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9690203,0.005157513,0.0003391615,0.0001399564,0.01447802,0.000006492571,0.0001923658,0.0003385421,0.0002715395,0.00006300174,0.0001954502,0.009797648],"study_design_scores_gemma":[0.9406495,0.004541436,0.002002538,0.000456125,0.03768278,0.00001294961,0.0001270892,0.006040819,0.00539443,0.002922552,0.00002019676,0.0001495731],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9169419,0.05715084,0.001843543,0.001638007,0.0003185892,0.02176967,0.0003188798,0.00001186839,0.000006701331],"genre_scores_gemma":[0.9973159,0.0003354677,0.0006154172,0.00002254819,0.0001210274,0.001490103,0.00003891626,0.00003647875,0.00002414258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.080374,"threshold_uncertainty_score":0.6343136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03632448289961169,"score_gpt":0.3509823022406565,"score_spread":0.3146578193410448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}