{"id":"W4285229704","doi":"10.1177/17588359221097940","title":"Characterizing the <i>KRAS</i> G12C mutation in metastatic colorectal cancer: a population-based cohort and assessment of expression differences in The Cancer Genome Atlas","year":2022,"lang":"en","type":"article","venue":"Therapeutic Advances in Medical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"","keywords":"KRAS; Medicine; Colorectal cancer; Population; Cancer; Oncology; Internal medicine; Mutation; Cancer research; Gene; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004814856,0.0001970027,0.000407502,0.001650045,0.000604699,0.0007484658,0.0004485721,0.0003686462,0.001054639],"category_scores_gemma":[0.00116543,0.0001936939,0.0002336978,0.002104555,0.0003637296,0.0002590631,0.0004373221,0.0003551939,0.0003294318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008384942,"about_ca_system_score_gemma":0.0006849777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0818069,"about_ca_topic_score_gemma":0.1151493,"domain_scores_codex":[0.9994862,0.00004895882,0.00004154582,0.0002007712,0.0001451412,0.00007732981],"domain_scores_gemma":[0.9991639,0.00006648766,0.000310309,0.00009646259,0.0002394269,0.0001235458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000465298,0.000004930414,0.9978124,0.00001003888,0.00003650418,0.00007662693,0.00004795259,0.00001933222,0.0007533408,0.00000963329,0.000134462,0.001048344],"study_design_scores_gemma":[0.000001120333,0.00001931939,0.999071,0.000003583475,0.00001775212,0.0003541395,0.00009120583,0.00004283146,0.00009023899,0.00000893896,0.0002971375,0.000002660139],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971864,0.0004119678,0.0001230354,0.00003845793,0.000003145778,0.00001533803,0.001730648,0.00000842514,0.0004826248],"genre_scores_gemma":[0.9980292,0.0002559012,0.0001003559,0.00003455348,0.000004877766,0.00001347821,0.001403326,0.000006660042,0.0001515462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0818069,"threshold_uncertainty_score":0.1626614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02920145447641013,"score_gpt":0.389178278416758,"score_spread":0.3599768239403478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}