{"id":"W4285275163","doi":"10.7202/1089787ar","title":"CRISPR Gene-Therapy: A Critical Review of Ethical Concerns and a Proposal for Public Decision-Making","year":2022,"lang":"en","type":"review","venue":"Canadian Journal of Bioethics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novo Nordisk Fonden; Novo Nordisk","keywords":"CRISPR; Mainstream; Autonomy; Engineering ethics; Beneficence; Ethical decision; Psychology; Political science; Biology; Gene; Social psychology; Genetics; Law; Engineering","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001753474,0.0002677021,0.001004173,0.0002126307,0.0001297903,0.00004535661,0.0004206153,0.0007332133,0.00009999705],"category_scores_gemma":[0.004993904,0.0002333494,0.0005354591,0.0001708772,0.0004126772,0.000003578703,0.0000625734,0.001192012,2.78784e-7],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006585807,"about_ca_system_score_gemma":0.00850457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004705376,"about_ca_topic_score_gemma":0.0007012553,"domain_scores_codex":[0.9980617,0.0002097886,0.0008761474,0.0002691831,0.0002486042,0.0003345672],"domain_scores_gemma":[0.9979054,0.0005494672,0.0003555592,0.0002861542,0.0004379476,0.0004654189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001859299,0.00001655585,0.000004255469,0.03813132,0.0002874222,0.00005715116,0.00006711576,0.000001733912,0.0000322188,0.001881997,0.00649314,0.9530085],"study_design_scores_gemma":[0.0001555518,0.0004612778,3.522958e-7,0.01781864,0.0002589921,0.0005860851,0.00003044447,0.000003389714,0.00004855475,0.0003057334,0.9800965,0.0002344981],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000006075772,0.9893773,0.007969053,0.00146092,0.0005002543,0.0004156972,0.0002407555,0.000001661838,0.00002824893],"genre_scores_gemma":[0.0002705585,0.9909182,0.007354251,0.0008378747,0.0004909945,0.00002601656,0.00004078016,0.00005463004,0.0000067462],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9736033,"threshold_uncertainty_score":0.9971163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1249971691138849,"score_gpt":0.4566454827008989,"score_spread":0.331648313587014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}