{"id":"W4285275163","doi":"10.7202/1089787ar","title":"CRISPR Gene-Therapy: A Critical Review of Ethical Concerns and a Proposal for Public Decision-Making","year":2022,"lang":"en","type":"review","venue":"Canadian Journal of Bioethics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novo Nordisk Fonden; Novo Nordisk","keywords":"CRISPR; Mainstream; Autonomy; Engineering ethics; Beneficence; Ethical decision; Psychology; Political science; Biology; Gene; Social psychology; Genetics; Law; Engineering","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01336661,0.001096761,0.001713773,0.005821144,0.001697557,0.004118952,0.002456975,0.008059136,0.00177595],"category_scores_gemma":[0.02107089,0.0005651526,0.001221419,0.004655154,0.009793309,0.005151491,0.002249526,0.008871405,0.0007381517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01018474,"about_ca_system_score_gemma":0.01811255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005921397,"about_ca_topic_score_gemma":0.007784593,"domain_scores_codex":[0.9924949,0.003743376,0.0007301539,0.0005129142,0.002198638,0.0003200526],"domain_scores_gemma":[0.9820321,0.01426176,0.0006385114,0.0003700255,0.00234462,0.0003530162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000633464,0.00007138241,0.0001304794,0.0187444,0.00009286655,0.0004555431,0.002003363,0.0009030577,0.0005598146,0.2569837,0.1918223,0.5281698],"study_design_scores_gemma":[0.00001436181,0.00003654629,0.0002702268,0.01891372,0.00004276448,0.0006592145,0.0007918224,0.0001514672,0.0002414534,0.05939401,0.91944,0.00004458034],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009357186,0.9718974,0.001128959,0.02217646,0.002635775,0.00001898297,0.00000990187,0.000009043726,0.002029878],"genre_scores_gemma":[0.004620787,0.9775493,0.001924386,0.01272195,0.001985918,0.0000770823,0.00002611093,0.000008872722,0.00108552],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01336661,"threshold_uncertainty_score":0.07389575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1249971691138849,"score_gpt":0.4566454827008989,"score_spread":0.331648313587014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}