{"id":"W4285292372","doi":"10.5267/j.ccl.2022.4.002","title":"Synthesis and anticancer properties of 3-furan-2-yl-2-(4-furan/thiophen-2-ylthiazol-2-yl)acrylonitrile derivatives","year":2022,"lang":"en","type":"article","venue":"Current Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute","keywords":"Acrylonitrile; Furan; Furfural; Chemistry; Acetonitriles; Medicinal chemistry; Cancer cell lines; Stereochemistry; Organic chemistry; Cancer; Cancer cell; Catalysis; Acetonitrile","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008791525,0.0002614422,0.0002184711,0.0002223623,0.0001310994,0.0001716632,0.0001878334,0.0001851546,0.001320174],"category_scores_gemma":[0.00008548155,0.0001277984,0.0002472072,0.0001607857,0.0001114761,0.0001295887,0.0001364778,0.0003380421,0.0004414532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000153934,"about_ca_system_score_gemma":0.0001817897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005205954,"about_ca_topic_score_gemma":0.0008325315,"domain_scores_codex":[0.9999431,0.000007979728,0.000004574003,0.000009785464,0.00001417413,0.00002033496],"domain_scores_gemma":[0.9999504,0.000005021699,0.00001322367,0.000004485754,0.000008999165,0.00001790935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008030278,0.00004759752,0.0000770152,0.0001022896,0.00000533085,0.0001301145,0.00002399085,0.0003194463,0.9957522,0.0001969456,0.00007463864,0.003189962],"study_design_scores_gemma":[0.00003711113,0.001131841,0.001960762,0.00001257214,0.00001661392,0.0003152055,0.00001830263,0.0005473492,0.9903024,0.00005538461,0.005586405,0.00001607759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766441,0.007704717,0.006812871,0.0002351344,0.0000598488,0.0001473082,0.0007601296,0.0001965279,0.007439388],"genre_scores_gemma":[0.9848139,0.002941541,0.006364514,0.00005833671,0.00001783084,0.00008272133,0.0007024068,0.00002157279,0.004997156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001320174,"threshold_uncertainty_score":0.004416466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03038467005625737,"score_gpt":0.2294478647044748,"score_spread":0.1990631946482174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}